Атлас лучевой диагностики опухолей опорно-двигательного аппарата - Веснин А.Г.
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J. A. Celia et al., J. Org. Chem. 24,1109 (1959).
R. M. Dodson et al., J. Am. Chem. Soc. 81,1224 (1959).
USP 3 137690 (Searle; ert. 16.6.1964; Anm. 26.9.1963).
Verbesserte Verfahren fur Vorprodukte:
USP 3 270008 (Searle; ert. 30.8.1966; GB-Prior. 1.10.1963).
USP 3 738 983 (Searle; ert. 12.6.1973; Anm. 6.8.1971).
824 S Spironolacton - Staliimycin
Verbesserte Thioessigsaure-Addition:
DOS 2 809 838 (Mitsubishi Chemical; Anm. 7.3.1978; J-Prior. 17.3.1977). b DBP 2 327 448 (Schering AG; Anm. 25.5.1973).
Weitere Verfahren:
GB-P 1444 272 (Hoechst; Anm. 27.7.1973; D-Prior. 28.7.1972).
GB-P 1447247 (Hoechst; Anm. 22.10.1973; D-Prior. 20.10.1972).
GB-P 1450425 (Hoechst; Anm. 4.10.1973; D-Prior. 5.10.1972).
GB-P 1 450693 (Hoechst; Anm. 4.10.1973; D-Prior. 5.10.1972).
DAS 1 250 818 (Searle; Anm. 30.9.1964; GB-Prior. 1.10.1963).
DOS 2 852 145 (Searle; Anm. 1.12.1978; USA-Prior. 2.12.1977).
GB-P 1 548259 (Ciba-Geigy; Anm. 11.6.1976; CH-Prior. 13.6.1975).
D: AldopurВ® 50 (Heumann)
AldactoneВ® (Boehringer Mannheim/Searle) AidactoneВ®-SaItucinВ®
(Boehringer Mannheim)-Komb.
Osyro)В® (Hoechst)
SincomenВ® (Schering)
Spiro-TablinenВ® (Sanorania)
F: AldactazineВ® (Searle)-Komb.
AldactoneВ® (Searle)
GB: A/dactideВ®(SearJe)-Komb.
AldactoneВ®-A (Searle)
I: AldactoneВ® (Lepetit)
IdrolattoneВ® (Zoja)
SincomenВ® (Schering)
SpirolongВ® (Smith KJine & French) UractoneВ® (Spa)
J: AldactoneВ®-A (Dainippon; Searfe-Marupi) AlexanВ® (Sanwa)
AlmatolВ® (Fujisawa)
AlpamedВ® (Sawai)
ApolasnonВ® (Nihon Iyakuhin)
DairopealВ® (Daito Koeki)
DiraВ® (Kakenyaku Kako)
LacaiminВ® (Tatsumi)
NefurofanВ® (Maruko)
OsyrolВ® (Hoechst)
Spironolactone (Towa)
SuractonВ® (Toho Iyaku)
USA: AldactazideВ® (Searie)-Komb.
AldactoneВ® (Searle)
Staliimycin 636-47-5 Antibioticum,
(Distamycin A) 6576-51-8 Hydrochlorid Virustaticum
N* '-(2-amidinoethyl)-4-formamido-l,r Р” "-trimethyl-N,-4': N' ,4"-ter(pyrrole-2-carboxamide) a Isolierung aus Fermentationslosungen von Streptomyces distallicus
РЎРќР·
/Р¦^РЎРћРћРќ
.РЈ
o2n
1-Methyl-4-nitro-
pyrrot-2-carbonsaure
1. SOCli
2. h?n-ch2-ch2-cn
1 Thionytcf>tori<3
2. 2--Aminopropionitril
CH3
pr
co-nh-ch2-ch2-cn
o2n'
2-{ J - Methyl-U - oitropyrrol -7- carbox-amido)-propВ»onitril
1 H2/Pd-C/0MF CH3
2. \J
0;N _J
2. !-Methyl-4-nitro-pyrrol- 2-carboo-saureclHond
tr
1. M2 /Pd—СIDMP СНз CH3
N'y^CO — NH — CH2~ CH2—CN ^ ^'C0_a
o2n_
2. i-Methyl-4-nitro-pyrrol-2-eaibon-
CH3 % if' 2
CO-NH
C^N'
2-[l-Methyl-4-(1-methyl-4-nitropyrrol-2-carbox-
amido)-pyrro!-2-carboxamido]-propjonitf)l
saurecKiorid
Stallimycin — Stanozolol S 825
CH3
вњ“n^CO-NH-CH2-CH2-CN
ch3 \Jr
I ' 1. HC1/C2HS0H
v-Nv^CO-NH 2. nhj;c2hsoh
CH3 \J
N^co-NH
pr
02N
2-{l-Methyl-4-[l-methyl-4-(1-methyl-4-nit ropyrrol-2-carboxamido)-pyrrol-2-carboxamido}-pyrrol-2-carboxamido}-propВ»omtril
|H3
/N4^C0-NH-CH2-CHj-C
^ V
^Ns^CO-NH
CH3
^Nn^CO—NH*
O2N
w
pr'-......
fru......
DOT 13,322 (1977).
a USP 3190 801 (Farmitalia; ert. 22.6.1965; I-Prior. 12.12.1956).
F. Arcamone et al., Gazz. Chim. Ital. 97,1097 (1967). b DBP 1470284 (Farmitalia; Anm. 22.7.1964; I-Prior. 26.7.1963). USP 3 420 844 (Farmitalia; ert. 7.1.1969; I-Prior. 26.7.1963).
F. Arcamone et al., Nature 203,1064 (1964). Ausgangsverbindung:
M. J. Weiss et. al., J. Am. Chem. Soc. 79,1266 (1957).
I: HerperalВ® (Farmitalia)
Stanozolol 104"l 8-03-8 Anabolicum
(Stanazol)
17-methyl-5В«-androstano[3.2-cJpyrazol-17/3 -ol
826 S Stanozolol - Streptokinase
17/3-Hydroxy-17cr-methyl-
2,3-СЃРљРСѓ<1РіРѕ-{2,4-ап<1РіРѕ5*ай1епо
(3,2-c jpyrazoli
a R. O. Clinton et al., J. Am. Chem. Soc. 81,1513 (1959).
R. O. Clinton et al., J. Am. Chem. Soc. 83,1478 (1961). b USP303035S (SterlingDrug; ert. 17.4.1962; Anm. 11.5.1961; Prior. 16.2.1959). Ausgangsverbindung:
R. O. Clinton, J. Am. Chem. Soc. 83, 1478 (1961).
D: StrombaВ® (Winthrop)
StrombajectВ® (Winthrop)
F: StrombaВ® (Winthrop)
StrombajectВ® (Winthrop)-Komb. GB: StrombaВ® (Winthrop)
I: AnasythВ® (Causyth) WinstrolВ® (Zambon)
J: WinstrolВ® (Yamanouchi) USA: WinstrolВ® (Winthrop)
Streptokinase 9002-01-1 Hbrinoiyticum
(Plasminogen-Aktivator)
co-enyzme obtained from cultures of various strains of Streptococcus haemolyticus and capable of changing plasminogen into plasmin
(komplexes Enzym-Gemisch aus Streptokinase, Streptodornase und Streptolysin ,,0“)
Aus den Fermentationsbriihen hamolytischer Streptokokken-Arten (Streptococcus haemolyticus), z.B. H 46 A.
USP 2 666 729 (Merck & Co.; ert. 1954; Anm. 1951).
USP 2 701 227 (American Cyanamid; ert. 1955; Anm. 1951).
USP 3 063 913 (Behringwerke; ert. 13.11.1962; D-Prior. 29.12.1959).
USP 3063 914 (Behringwerke; ert. 13.11.1962; D-Prior. 22.12.1959).
Streptokinase - Streptomycin S 827
Reinigungsverfahren:
USP 2 753 291 (American Cyanamid; ert. 1956; Anm. 1954). USP 3 016 337 (Ortho Pharmac. Corp.; ert. 9.1.1962; Anm. 27.4.1959). USP 3 042 586 (Merck & Co.; ert. 3.7.1962; Anm. 29.9.1959). USP 3 107 203 (Merck & Co.; ert. 15.10.1963; Anm. 24.11.1961). USP 3 138 542 (Behringwerke; ert. 23.6.1964; D-Prior. 31.12.1959).
