- - ..
( ):
Orthoameisen-
sauretnethylester
H5C2O H Proscillaridin-2 ',3'-ethylorthoformiat
Meproscillarin - Meprylcain - Mepyramin M 561
о
1 CH3I / DMF/ NaH
2 HQ /СНзOH
HO OH
Meproscillarin
DOF 2,400 (1977).
DOT IS, 281 (1979).
DOS 2 301 382 (Knoll; Anm. 12.1.1973).
DOS 2427 976 (Knoll; Anm. 10.6.1974).
H. Kubinyi, Arzneim. Forsch./Drug Res. 28, (I), 491 (1978). Weitere Verfahren:
DBP 1 910 207 (Knoll; Anm. 28.2.1969).
H. Kubinyi, Arch. Pharm. Ber. Dtsch. Pharm. 304, 531 (1971). Kombination mit Verapamil:
DOS 2746881 (BASF; Anm. 19.10.1977).
D: Clift® (Knoll)
Meprylcain 495-70-5 Lokalanastheticum
2-methyl-2-propylaminopropyl benzoate
CH3
Benzoyl chlorid (11-Dimethyl-2-hydro*)'-
ethyO-propylamm
CH3
Meprylcain
USP 2 421129 (Oradent Chem.; ert. 1947; Prior. 1944). Lokalanasthetisch wirksame Injektionslosung:
USP 2 767 207 (Mizzy Inc.; ert. 1956; Prior. 1953).
J: Epirocain® (Eisai)
USA: Oracaine® (Mizzy)
Mepyramin
(Pyrilamin)
91-84-9
6036-95-9 Hydrochlorid 59-33-6 Maleat
Antihistaminicum
2-[(2-dimethylaminoethyl)(/?-methoxybenzyl)amino]-pyridine
562 M Mepyramin - Mequitazin - Merbromin
н3со
CHQ ♦ I
N HCOOH
Afncis#n-
saure
4-Methoxy- 2-Amino-
benzaldehyd pyridin
H3CO^>CH,
NH
d
2-(4-Methoxybenzyt-
aminol-pyridin
1 NaNH2
2. CI-CH2-CH2-N(CH3]2 — ■ >
1. Natnumarmd
2. 2-0imethylamino-ethylchtond
CH3
‘N-CH2-CH2-N
CH3
Mepyramin
USP 2502 151 (Rhone-Poulenc; ert. 1950; F-Prior. 1943).
D: Triaminic® (Wander)-Komb. Triaminic® (Salvoxyl-Wander)-Komb.
F: Asphogan (Coop. Pharmac. Franc.)-Komb. Triatussic® (Salvoxyl-Wander)-Komb.
Nortussine® (Norgan)-Komb. GB: Anthisan® (May & Baker)
Mequitazin 29216-28-2 Antihistaminicum;
Sedativum
10-(3-quinuclidinylmethyl)phenothiazine
oco *
Natnumhydnd
3-Chlormethyl-
chinuclidin
DOT 15,199(1979).
DOS 2 009 555 (Sogeras; Anm. 28.2.1970; GB-Prior. 3.3.1969).
D: Metaplexan® (Badische Arzneimittel) Vigigan® (Spret-Mauchant)
F: Primalan® (Spret-Mauchant) GB: Primalan® (Berk)
Merbromin 145-53-9 Antisepticum
(Mercurochrom) 129-16-8 Di-Na-Salz
disodium salt of 2,7-dibromo-4-hydroxymercurifluoresceine
Merbromin - Mercaptopurin - Mesna M 563
2,7-DibromfhJOrescein
USP 1 535 003 (E. C. White; ert. 1925; Prior. 1921).
D: Mercurochrom®-Losung (Krewel) X: Mercurocromo® (Sit)
F: Curichrome® (Groupil) USA: Mercurochrome® (Hynson, Westcott & Dunning) *
Mercurochrome® (Lab. du Mercurochrome)
Mercaptopurin 50-44-2 Cytostaticum
6-purinethiol
PhosphorlV)-
sulfid
SH
H
Mercapto-
purin
OH
trs
Sl-^N
H
6-Hydroxy-
purin
(Hypoxanthin)
GB-P 713 286 (Wellcome Found.; Anm. 1951). Alternativ-Synthesen:
USP 2 721 866 (Burroughs Wellcome; ert. 1955; Anm. 1954). USP 2 724 711 (Burroughs Wellcome; ert. 1955; Anm. 1954). USP 2933 498 (Burroughs Wellcome; ert. 1960; Anm. 1954).
D: Puri-Nethol® (Wellcome)
F: Purinethol® (Wellcome)
GB: Puri-Nethoi® (Burroughs Wellcome) I: Ismipur® (Ism)
Purinethol® (Wellcome)
J: Classen® (Nippon Shoji)
Leukerin® (Takeda)
Mem® (Tanabe)
6-MP (Dojin)
Thioinosie (Morishita)
USA: Purinethol® (Burroughs Wellcome)
Mesna 3375-50-6 Detoxicans;
19767-45-4 Na-Salz Mucolyticum
sodium 2-mercaptoethanesulfonate
H2N
C=S + Br-CH2-CH2-S03H
H2N
Thioharn- 2-Bromelhansulfonsaure
stoff
HN
C-S-CH2-CH2-S03H -I HS — CH2 —CH2—SO3H I
lW !
564 М Mesna - Mesoridazin - Mestanolon
DOT 8,180 (1972).
USP 2 695 310 (Lever Brothers; ert. 1954; Anm. 1951).
С. H. Schramm et al., J. Am. Chem. Soc. 77,6231 (1955).
USP 3 567 835 (UCB; ert. 2.3.1971; GB-Prior. 7.5.1965) — nur mediz. Anw. Aus Ethylensulfid und Natriumhydrogensuffit:
W. Reppe, Justus Liebigs Ann. Chem. 601,127 (1956).
Aus 2-Chlorethansulfonsaure und NaSH:
DRP 619 299 (Henkel; Anm. 1933).
Detoxicans bei der Therapie mit Cyclophosphamid und Ifosfamid:
DAS 2 756018 (Asta-Werke; Anm. 14.12.1977).
Salze mit Aminen (Mucolytica):
DAS 1620629 (UCB; Anm. 5.5.1966; GB-Prior. 7.5.1965).
D: Mistabronco® (UCB) Mucofluid® (UCB)
Uromitexan® (Asta) F: Mucofluid® (UCB)
Mesoridazin 5588-33-0 Psychosedativum
32672-69-8 Benzolsulfonat
10-[2-(l-methyl-2-piperidyl)ethyJ]-2-(methy]sulfiny])-phenotbiazine
CO-CH3
2-Methylthio-
phenothia2in
Acetanhydrid
SO—CH;
k2co3/ch3oh
SO-CH3
C0-CH3
H
2-Methylsulfinyl
phenothiazin
H3C
Mesoridazin
DOT 9,227(1973).
USP 3 084 161 (Sandoz; ert. 2.4.1963; CH-Prior. 10.3.1960).
F: Lidanil® (Saivoxyl-Wander)
USA: Serenti]® (Sandoz)
Mestanolon 521-11 9
17/3 -hydroxy- 17-methyl-5a-androstan-3-one
Anabolicum
Mestano/on - Mesterolon M 565
CH3MgBr
Methyl-
magnesium-
bromid
H0*‘
Chrom(VI)-oxid
Methyltestosteron Mestanolon
(s. s. 568)
a GB-P 464 396 (Schering AG; Anm. 1935).
L. Ruzicka et al., Helv. Chim. Acta 18, 994,1487 (1935). Ausgangsverbindung:
The Merck Index, 676 (Rahway 1976). b USP 2 763 670 (Syntex; ert. 1956, MEX-Prior. 1954).
GB: Androstalone® (Roussel) J: Andoron® (Sawai)
Mestalone (Hokuriku) Methyantalon® (Sanwa) Prohormo® (Toyo P.)
Protenolon® (Showa)
