- ..
ISBN 978-5-9704-0578-9
( ):
F: Parfenac® (Lederle)
GB: Feximac® (Nicholas)
Parfenac® (Lederle)
I: Parfenal® (Cyanamid)
J: Anderm® (Nikon Lederle)
Buflomedil - Bumadizon - Bumetanid В 121
Buflomedil 55837-25-7 Vasodilatator;
35543-24-9 Hydrochlorid Spasmolyticum
2,,4',6'-trimethoxy-4-(l-pyrrolidinyl)butyrophenone
иО
NC-CH2-CH2-CH2-CI -NC--CH2-CH2-CH2-N J
PyrraUdm
Д-Chlotbutyroriitnl 4-Pyrrolidinobutymnitril
НзС0^\1^ /HCl 0CN3
t,3,5- Trimethoxybenzol
GB-P 1325 192 (Orsymonde; Anm. 6.5.1970; Laufzeit ab 6.5.1971).
F: FonzyIane®(Lafon)
BlimadiZOn 3583-64-0 Antiphlogisticum;
34461-73-9 Ca-Sa(z Antipyreticum Semihydrat
butylmaionic acid mono( 1,2-diphenylhydrazide)
Phenylbutazon \ Bumadizon
(S. S 720) -
DOT9,14 (1973).
USP 3 455 999 (Geigy; ert. 15.7.1969; CH-Prior. 7.6.1963).
DBP 1 235 936 (Geigy; Anm. 5.6.1964; CH-Prior. 7.6.1963).
DBP 2 055 845 (Byk Gulden; Anm. 13.11.1970).
D: Eumotol® (Byk Gulden) F: Eumotoi® (Valpan)
Rheumatol® (Tosse) 1: Eumotol® (Byk Gulden)
Bumetanid 23395031
3-(butylamino)-4-phenoxy-5-sulfamoylbenzoicacid
Diureticum
122 В Bumetanid - Bunamiodyl
CI-SOj__H2N—SO2.__Q-ON HjN—S(V_
c,hQ-cooh -паи а-0-соон <Qbo-^cooH
02N 02N lto-s.12! 0zN
4-Chlor-3-chlorsulfonyl- 5-Aminosulfonyl-4- 5-Aminosulfonyl-3-mtro-
5-nitrobenzoesaure chlor-3-nitrobenzoesaure 4-phenoxybenzoesaure
H2N
3-Amino-5-ammosulfonyt-
4-phenoxyben2oesaure
H9C*-NH
Bumetanid
DOT 8,238 (1972); 9,449 (1973).
GB-P 1 249 490 (Loevens Kemiske Fabr.; Laufzeit ab 22.12.1969; Prior. 24.12.1968,18.6.1969, 29.7. 1969).
DAS 1966 878 (Loevens Kemiske Fabr.; Anm. 23.12.1969; GB-Prior. vgl. GB-P 1 249 490).
USP 3 634 583 (Loevens Kemiske Fabr.; ert. 11.1.1972; Anm. 24.7.1969).
D: Fordiuran® (Thomae) I: Burinex® (Sigma Tau)
F: Lixil®(Leo) J: Lunetoron®(Sankyo)
GB: Burinex® (Leo)
Bunamiodyl 1233-53-0 Rontgenkontrastmittel
(Buniodyl) 1923-76-8 Na-Salz
2-(3-butyraimdo-2,4,6-triiodophenylmethylene)biityric acid
PKh=<(
o2n
p2Hb
COOH
H2/Rarwy-Ni/55°C
a-Ethyl-3-nitro-
zimtsaure
(vgl. topansaure-Syrtfhese, S. 495)
Я2Н5
CH=C
h2n
«-Ethyl-3-amjno-zimtsaure
M
H,N I
CH=C
Jodmonc-
chlorid
(Н7С3-СО)гО
Butlersaure-
anhydrid
C2HS
К
; H7C3-C-NH i и 0
Bunamiodyl
H. Cassebaum, K. Dierbach. Die Pharmazie 16, 392 (1961).
D: Orabilix® (Hefa-Frenon) J: Orabilix® (Kodama)
F: Orabilix® {Guerbet)
Bunitrolol - Buphenin В 123
Bunitrolol 34915-68-9 Betablocker
o-[3-(/^r/-butylamino)-2-hydroxypropoxy]benzonitri]e
CN
2-Hydroxy-
benzonitrit
fZ-Cyanophenol)
О
A
VCH2-Cl
Epichlorhydrin
(Q-o-CHz—C?
CN
I/ y-0-CH2-CH-CH2-NH-CICH3)3
CN
I
OH
DOF 1,210(1976).
DOT 13,15(1977).
DAS 1 593782 (BoehringerIng.; Anm. 15.6.1967).
USP 3 541 130 (Boehringer Ing.; ert. 17.11.1970; D-Prior. 6.2.1967,15.6.1967,25.7.1967). Weiteres Verfahren:
DOS 2 503 222 (Boehringer Ing.; Anm. 27.1.1975).
D: Stresson® (Boehringer Ing.)
Buphenin
(Nylidrin)
447-41 -6 849-55-8
Hydrochlorid
Vasodilatator;
Sympathomimeticum
l-Q>hydroxyphenyl)-2-(l-methyl-3-phenylpropyl-amino)-l-propanol
0
4-Hydroxypropiophenon
H04\ /y—C~CHz—CH3 + 0
0~CH2-C
Benzylchlorid
C~CH2-CH3
4-Benzyloxypropiophenon
QbCHj-OMQ^-с-сн-Вг
0 CH3
HjN—CH-CHj —CH2 -Q CHj
3-Butyl-1-phenylamin (1-Methyl-3-phenytpropylamin)
^СН2-С-{>С-СН-МН-СН-СН2-СН2Ч[} ■ HBr
0 CH3 CH3
Hz/Pd-C
HO - CH - NH -CH -CH 2 -CH2
ОН СНз СНз Buphenin
124 В Buphenin - Bupivacain
но
■О-
СН-СН“ЫНг ОН СНз
н3с
‘с_сн2-снг^>
1-U-HydroxyphenyU-propa-nol-2-amin [l-(4-Hydroxy-phenyl)-2-amino-1-propanol]
Benzylacetori
(t-Phenyl-3-butanon)
Buphenin
a USP 2 661 373 (F. Kiilz, C. Schopf; ert. 1953; Prior. 1953). DBP 815 043 (Troponwerke; 1948). DAS 1 182 245 (Philips; Anm. 19.1.1962; NL-Prior. 23.1.1961). b USP 2 661 372 (Troponwerke; ert. 1953; Prior. 1949).
D: DiJatol® (Tropon)
F: Agyrax® (Ucepha)-Komb. Escino® (Doms)-Komb. Escinogel® (Doms)-Komb. I: Opino® (Bayropharm)
J: Nyderal® (Kobayashi K.)
Nylidrin. HCl Tab, (Toyo P.) Nylin® (Toho)
Shatom® (Seiko Hiyo) Verina® (Fujisawa)
USA: Arlidin®(USV)
Bupivacain
(Marcain)
2180-92-9
18010-40-7
Hydrochloric!
Lokalanastheticum
l-butyI-2',6'-pipecoloxylidide
ch3
CH,
2,6-Dimethyl-
aniiin
(2,6-Xylidin)
CH3
}-o —
Cl
Pyridin-2-
carbonsaure-
chlorid
CH3
Qf-Picolinsaure-2,6-
xylidid
CH3
0“
CH3
CtH9Br
NH-C-U +N = 0 / C4Hg
CH3
* rHIv
СНз 0c1h,
Bupivacain
CH3
Jr=J /-4 /-V. C4HgBr
<Q-nh2 * У-Q * Q
Ct и о H
и
CH, 1-1 H ’CH3
NH—C—( ) -—► Bupivacain
2,6-Dimethyl- Pipecolinsaure-anilin chlorid
(Piperidin-2-
carbonsaurechlorid)
Bupivacain - Bupranolol - Busuifan В 125
DOT 3,88 (1967).
DBP 1 161 900 (AB Bofors; Anm. 19.7.1955; S-Prior. 6.4.1955).
DBP 1 169941 (AB Bofors; Anm. 19.7.1955; S-Prior. 28.4.1955).
GB-P 869 978 (AB Bofors; Anm. 13.2.1959; S-Prior. 13.3.1958).
B. af Ekenstam et al., Acta Chem. Scand. 11, 1183 (1957).
Alternativsynthesen:
USP 2 792 399 (AB Bofors; ert. 1957; S-Prior. 1954).
