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ISBN 978-5-9704-0578-9
( ):
Cl—CH2—CH—CH2—N
CH2-CH2-OH
h,C- Ji H
Juft I
0 N N
O^M^N
I
CH,
OH (
I /
о CH2-CH-CH2-N
« / 1 1 \
сн2-сн2-он
aC(
I
on
о CH2-CH-CH2-N
CH2-CH2-OH
M
I
CH3
■o’
.COOH
Xantinol-nicotinat
USP 2 924 598 (J. A. Wiilfing; ert. 9.2.1960; D-Prior. 26.10.1957).
D: Complamin® (Wiilfing)
F: Complamine® (Latema) GB: Complamex® (Gemini)
I: Angioamin® (Dompe)
Complamin® (Italchimici)
Emodinam® (Sigurta) Vasoprin® (Alfa Farm.) Vedrin® (Polifarma) USA: Complamin® (Riker)
952 X Xibornol - Xipamid
Xibornol
13741-18-9
Broncho-Chemo-
therapeuticum
6-isobornyl-3,4-xyIenol
- v
CH2 Camphen
CH3 3,4-Xylenol
{SnCI; j ; 7D-90°C иnd chromatograph R&inigung
CH2
Camphen
H3C CH3
H3C0 H °x^3
К CH3 /Х^-'Л-сиз
CH3
3,A-Dimethylan!soI
CH3
a GB-P 1206 774 (Mar-Pha; Anm. 23.10.1967). b DOS 2 032 170 (Mar-Pha; Anm. 30.6.1970; GB-Prior. 4.7.1969).
F: Nanbacine® (Furnier-Freres)
Xipamid
14293-44-8
Diureticum
4-chloro-5-sulfamoyl-2',6'-saiicyloxylidide
ss^cooh
A
4-СЫог-
salicylsaure
CtS03H
Chlorsulfon-
saure
Cl—S02 ^^COOH О-^Ч^ОН
H2N-S02^rv^C00H
Д
5 - Aminosuifonyl -4 -chlor -salicylsaure
H3C
H,N
H,C
■-£}/f
2,6-Oiwethyl- I Phosphw(IJJ)-
H^N-SOj Cl‘
о НзС H3c
Xipamid
DOT 7,227(1971).
USP 3 567 777 (Beiersdorf; ert. 2.3.1971; D-Prior. 19.6.1965). DBP 1270 544 (Beiersdorf; Anm. 19.6.1965).
D: Aquaphor® (Beiersdorf)
Durotan® (Beiersdorf)-Komb. mit Reserpin
GB: Diurexan® (Merck)
Xylometazolin-Zeranol-Zipeprol X/Z 953
Xylometazolin 526-36-3 1218-35-5 Hydrochlorid Vasoconstrictor; Rhiniticum
2-(4-ferf-butyl-2,6-dimethyIbenzyl)-2-imidazoline
СИ, /Из НзС-i-rich2-cN * H2N-^2 J«!U ' M Н^~СН2 CH3 CH3 ли сн3 ! N. CH3 \H, H
4-ferf-Butyl-2,6- Ethylen- Xylometazolin |
dimethylbenzyicyanid diarmn
USP 2 868 802 (Ciba; ert. 13.1.1959; CH-Prior. 10.7.1956). DBP 1 049 387 (Ciba; Anm. 3.7.1957; CH-Prior. 10.7.1956).
D: Ilvanol® (Siegfried) Otriven® (Ciba) GB: Otrivine® (Ciba) Otrivine-Antistin® I: Otrivin® (Ciba) USA: Otrivin® (Geigy) (Ciba)-Komb. mit Antazolin
Zeranol 26538-44-3 (Zearalanol) Oestrogen
3,4,5,6,7,8,9,10,ll,12-decahydro-7,14,16-trihydroxy-3-methyl-lH-2-benzoxacyclotetradecin-l-one
OH 0 СНэ '• Нг/Raney-Ni I I 2. fraktionierte KnstaUisation 1 OH 0 CH3 1
j
Zearalenon [ Zeranol !
DOT 12,243(1976). DBP 1 543 395 (Commercial Solvents Corp.; Anm. 1.2.1966; USA-Prior. 15.2.1965). USP 3 239 345 (Commercial Solvents Corp.; ert. 8.3.1966; Prior. 15.2.1965). Ausgangsverbindung: The Merck-Index, 9775 (Rahway 1976).
I: Frideron® (Sandoz) Raigro® (Commercial Solvent) Ralone® (Ш)
Zipeprol 34758-83-3 Antitussivum 34758-84-4 Dihydrochlorid
cr-(cr-methoxybenzyl)-4-(/3-methoxyphenethyl)-l-piperazineethanol
954 Z Zipeprol-Zolimidin
fyCH = C
СНзОН
(H3O3C —0 —Br -► <^^-CH-CH2-Br
Styrol
ferf-Butylhypo-
bromit
OCH3
2-Methoxy-2-phenyl-
ethylbromid
Piperazin
CH = CH-CH2-OH + CH3OH + (Н3С13С-О-БГ
Zimtalkohol
ferf-Butylhypo-
bromit
CH - CH2 - = Q]
ОСНз
1-[2-Methoxy-2-phenylethyl)-
piperazm
Br
<^^>-СН-СН-СНг-ОН
ОСНз
- m
OCH3
3-Methoxy-3-phenyl-
1,2-propylenoxid
Ш * SI
<^>-CH--CH;-N^N-CH;—CH —OH— ОСНз ОН ОСНз
Zipeprol
USP 3 718 650 (Mauvernay; ert. 27.2.1973; F-Prior. 2.3.1970).
F: Respilene® (Winthrop) I: Respilene® (Sigmatau)
Zitoxil® (Farmochimica)
Zolimidin 1222-57-7 Ulcustherapeuticum
2-[p-(methylsulfonyl)phenyl]imidazo[l,2-a]pyridine
* Br-CH2-C—(^~~V-S02-CH3 D'“an > V~SO2-CH3
N-^Nh2 W I^N-У W
! I
2-Amino- ш-Brom-i-methylsulfonylacetophenon j Zolimidin [
pyridin
GB-P 991 589 (Lab. Bioterapico Milanese Selvi; Laufzeit ab 23.7.1963; I-Prior. 30.4.1963) L. Almirante et al., J. Med. Chem. 8,305 (1965).
I: Solimidin® (Selvi)
USA: Mutil® (Lakeside)
Zomepirac Z 955
Zomepirac 33369-31-2 Analgeticum;
Antiphlogisticum
5-(p-chlorobenzoyl)-l,4-dimethylpynole-2-acetic acid
0 0
и II
Н5С2ООС-СН2-С-СНг-СООС2Н5 + CH3-NH2 + CI-CH2-C-CH3
Acetondicarbonsaurediethyiester Methylamin Chloraceton
i 1 a—((^-co-ci/Aici3 / ci-ch2-ch2-ci
^ycH2-cooc2H5 2 Na0H%_
1 4-Chlo»benzovlchlorid
H3C COOC2H5
1,4- Dimethyl - 3 - ethoxycar bo-nylpyrrol-2-essigsaureethylester
USP 3 952 012 (McNeil; ert. 20.4.1976; Prior. 16.2.1973, 26.1.1970,1.7.1968, 26.7.1967). J. R. Carson, S. Wong; J. Med. Chem. 16,172 (1973).
Weitere Verfahren;
Belg-P 762 060 (McNeil; Anm. 26.1.1971; USA-Prior. 26.1.1970).
DOS 2 339140 (McNeil; Anm. 2.8.1973; USA-Prior. 3.8.1972).
USP 3 865 840 (McNeil; ert. 11.2.1975; Prior. 16.2.1973, 26.7.1967,1.7.1968,26.1.1970).
D: Zomax® (Cilag) F: Zomax® (Cilag)
USA: Zomax® (McNeil)
a Ausgewahlte Stoffklassen
A
Acridine
Aaiflavimumchlorid 14 Dimetacrin3I6 Ethacridin 366 Mepacrin 555
Adamantane
Amantadin 33 Tromantadin 930
Alkaloide und Derivate
Ajmaiin 18 AJcuroniumchlorid \ g Atropin 63
Atropmmethonitrat 64 Bietaserpm 105 Bromocnptin 114
Butylscopolammonium-bro-midl32 Chinidin 182 Chinin 183 Deserpidin 272 Dihydroergocristin 307 Dihydroergotamin 307 Dihydroergotoxin 308 DimethylUjbocurarinium-ch!orid3I9 Eburnamonin 344 L‘(-)-Ephedrin 347 Hrgometrin 352 Ergotamin 353 Glaziovin 442 Methylergometrin 584 Methysergid 590 Nicergolin 629 Pilocarpin 726 Prajmaiium-bitartrat 744 Rescinnamin 801 Reserpin 802 Scopolamin 815 Syrbsingopin 853 Tubocurarinchlorid 934 VinbJastin 943 Vincamin 944 Vincristin 948 Vmdesin 948
