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Атлас заболеваний полости рта - Ланге Р.П.

Ланге Р.П., Миллер К.С. Атлас заболеваний полости рта — М.: ГЭОТАР, 2008. — 224 c.
ISBN 978-5-9704-0578-9
Скачать (прямая ссылка): pharmazeutischewirkstoffe1982.djvu
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1. Natriumamid
2. 3-Dimethylammo-propylchtond
1-Azaphenothiann
OOW-PyridoO^-b]-
1,4-benzothiazin)
N N
ch2-ch2-ch2*-n
Prothipendyl
DBP 1 001 684 (Degussa; Anm. 1954).
USP 2 974 139 (Degussa; ert- 7.3.1961; D-Prior. 2.10.1954).
D: DominalВ®/-forte (Homburg) ItridalВ® (Homburg)-Komb.
GB: TolnateВ® (Smith Kline & French) J: ProsylВ® (Kanto)
780 P Protionamid - Protirelin
Protionamid 14222-60-7 Tuberkulostaticum
(Prothionamid)
2-propylthioisonicotinamide
COOC2H5
COOC2H5
Oxatsaure-
diethylester
H3C—С “СзНч
1!
Рћ
СЃРѕРѕСЃ?РЅ5
I
* СЃРЅ2
Рћ' РЎ3Рќ7
2,4-01РѕС…РѕРер1ап-
saureethylester
(Butyroylbrenztrau-
bensaureethylester)
N = C-CH2-C0-4Hj
CDOH
“A
c3H7
Рё d '
6-Propyl-2-pyndon-
4-carbonsaure
1 Poo^/PCJs
2 C2H5OH
I PhospftorcxycMorid/ Phosphor (V)-chlorid
COOC2H5
H2/Pd
C(^vN^C3H7
2-Chlor-6-propyl~
isonicctinsaure-
ethylester
COOC2Hs
'C3H7
2-Propyliso-
nicotinsaure-
ethytester
'C3H7
2-Pr0pylis0'
nicotinsaure-
amid
C3H7
2-f3ropyliso-
mcotinsaure-
mfrrt
N C3H7 Protionamid
DOT 3,24(1967). GB-P 800250 (Chimie et Atomistique; Anm. 26.3.1957; F-Prior. 27.3.1956,19.4.1956,6.8.1956, 7.12.1956). S. Libermann et al., C. R. Acad. Sci. 242,2409, 2412 (1956).
D: EktebinВ® (Bayer)
Isoni-Pro Dap (Saarstickstoff-Fatol)-Komb. Peteha Dragees (Saarstickstoff-Fatol)
F: Trevintix (Theraplix)
GB: TrevintixВ® (May & Baker)
J: EntelohlВ® (Kyowa)
Prothionamide (Toho) Protionamid (Lederle-Takeda) TuberaminВ® (Meiji)
TuberexВ® (Shionogi) TubermideВ® (Sankyo)
Protirelin 24305-27-9 Antidepressivum;
(TRH; Thyroliberin; Tyroliberin) Schilddrusen-diagnosticum
5-oxo-L-prolyl-L-histidyl-L-prolinamide
Protirelin P 781
V
Z = Benzyloxycaibonyl — С — Q—СНг—
РћРЎРќР·
0 :h В§
OCHj
Р СѓРі = 5-Pyrrolidon- 2 - carbonsaure (Pyrogljtaminsaurel OMe * Methytester
Mbh = Dimethoxybenzhydryl -CH
Mbh-NH Р› I
CH2
CH2
/CH^ z—NH COOH
/>/“-• Benzyloxycar bonyl-/^-(i/'-dimethoxybenz-hydryl)- L-glutamin * Z-Gln(Mbhl-OH
H2N РЎРћРћРЎРќР· I
CH2 * 2 HCt
’Ln'h
l - Histidinmethylester- Dihydro-chlortd
H-His-OMe • 2 HCl
00N
/dmf/h5c2-n 0
/Q-“
c=n-0
1-HydrOxy-
benzotriazol
A/-ВЈthylmcrpMin / Dicyclohexytcaroo-dnmid
Mbh—MH^ ^0
?
CH2
CH2 * 2 HCl
I H
CH^ _N. COOCH3 Z-NH РЎ CH I! I
0 CH2
N*^
NH
Z - Gin {Mbh) - His—OMe
NaOH/Dioxan/HzO
Mbh—NH. .0 I
CH2
I
CH2
I H
XK XOOH
Z-NH РЎ CH
II i 0 CH2
Р”
t-NH
Z-Gin (Mbh)-His—OH
DMF/ ^-"C0NHl . HC, 1 f hsC7-N^O/(^^N=C=N-<^>
i*Prolinamid-
Hydrochlorid
1-Hydroxy- A/-Ethylmorpr'Olm / Dicyetchexyicarbo-benzotriazcl diimid
Mbh-NH .0 ^C*
f
РЎРќРі
i
СЃРЅРі
I
CH^ Z-NH C"
0 CH2 NH
Z-Gin (Mbh)- His - Pro~’NH2
В°=o.
N-V
Triftooressigsaure-Aiiiaol (9 ’) ; RLickUufl 1,5 h
CH
I
СЃРЅРі
~"0
782 P Protirelin - Protizinsaure
a Synthese:
W. Konig u. R. Geiger, Chem. Ber. 105,2872 (1972).
Startprodukt:
W. Konig u. R. Geiger, Chem. Ber. 103,2041 (1970).
G. Flouret, J. Med. Chem. 13, 843 (1970). b Anwendungen: als Antidepressivum:
USP 3 737 549 (Abbott; ert. 5.6.1973; Anm. 20.3.1972).
DOS 2 313 635 (Abbott; Anm. 19.3.1973; USA-Prior. 20.3.1972). bei verminderten BewuBtseinszustanden (impaired consciousness):
DOS 2 611976 (Takeda; Anm. 20.3.1976; GB-Prior. 3.4.1975, 26.11.1975). USP4059 692 (Takeda; ert. 22.11.1977; GB-Prior. 3.4.1975, 26.11.1975). zur Beseitigung von Schizophrenic:
GB-P 1 540574 (Takeda; Anm. 23.5.1975; Laufzeit ab 24.5.1976). Injizierbare Losungen (unter Verwendung von Zuckeralkoholen):
DOS 2 743 586 (Takeda; Anm. 28.9.1977; J-Prior. 1.10.1976).
AntepanВ® (Henning Berlin) F: Protireline В«RocheВ» (Roche)
RelefactВ®TRH (Hoechst) Stimu-T.S.H. (Roussel)
Thyroliberin/TRF Merck (Merck) GB: RelefactВ® (LH-RH/TRH (Hoechst)
TRH (Ferring) I: RelisormВ® T (Serono)
J: TRH (Tanabe)
Protizinsaure 13799-03-6 Antiphlogisticum
(Acide protizinique)
7-methoxy-a,10-dimethylphenothiazine-2-aceticacid
XX,
3-Ammo-4-brom-amsot
1 MaNQj /РќРЎ1 5
//
2. H5C2O-C
2 Kaliumethyl-xanthogenat
H3C0->^Y-SH
XIS,
2-Brom-5-methoxy-
thiophenol
Р·Р°,.
Q;N
4-Chlor-3-nitro-
acetophenon
РќР·РЎРћ.
CH3I/CH3OH; I00ec
РЎРћ-РЎРќР·
2-Acetyl-7-methoxyphenothiazm
В°rOa,
1
CH3
'РЎРћ-РЎРќР·
2 -Acetyl - 7-methoxy-10-methyl-phenothiazin
XXXKrJ ' xxxx,
СЉ
'—О
CH2-C v Nr ^'^Cty-COOH
РЎРќСЌ ,N~\ РЎРќР·
Protizinsaure - Protokylol - Protriptylin P 783
n-VrVi NaOC;H5 /0=C[QCiHi);
Diethylcafbonat 4sВ» Js. -A.
'V/ N'^-'^СНг—COOCH3 ^^Г^ХН-СООСНз CH3 CH3 COOC2H5
НзСО^ ^ s ^ ’ NaOH/C2H5OH
^ ХХ,ХЪ* ——
jodid N
I / РЎРћРћРЎРќР· РЎРќСЌ COOC2H5
USP 3450698 (Rhone-Poulenc; ert. 17.6.1969; F-Prior. 29.10.1964). F: PirocridВ® (Theraplix)
Protokylol 136-70-9 Sympathicomimeticum;
136-69-6 Hydrochlorid Broncholyticum
a-[[(a-methyl-3,4-methylenedioxyphenethyl)amino]-methyl]protocatechuyl alcohol
Р»>- C-CH2-CI * H2N-CH-CH2-<v f
HO
w-Chlor-Sjt-dihydroxy- 1-Mefnyl-2-(3lA-methylen-
acetophenon dioxyphenyl)-ethylamin
—/S ' ^ ?Нз r-4°"l ■
=\ Р” H2/Pt0 ! f=\ I /=\ I \
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