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.., .. .: , 2008. 224 c.
ISBN 978-5-9704-0578-9
( ): pharmazeutischewirkstoffe1982.djvu
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H,C0-^ f H3co
CH3
-с-COOH I
NH,
(il-S-OjA-Dimethoxyphenyl)-
2-methylalanin
1. //-Acetylierung
2. Razefnatspallung mit l-)-1-Ph«nylethylamin
3. HBr
_ снз !
HO-\ V-CH2-C-COOH I
нсГ
-Methyldopa
_ CH3
H3CO-4 ^СНз-С-СООН Н3СО NH2
(i)-3-(3,4-Oimethoxyphenylb 2-methylalanm
(i)-Methyldopa
selektive Kristallisation der Hydrogensuifit-Salae
(-)-Methyldopa
a USP 2 868 818 (Merck & Co.; ert. 13.1.1959; Prior. 15.12.1953).
GB-P 936 074 (Merck & Co.; Anm. 18.10.1960; USA-Pnor. 8.4.1960, 24.8.1960). E. W. Tristram et al.; J. Org. Chem. 29,2053 (1964). b G. A. Stein et al., J. Am. Chem. Soc. 77, 700 (1955). Chem. Engng. v. 8.11.1965; S. 247. USP 3158648 (Merck & Co.; ert. 24.11.1964; Prior.l 1.7.1961, 9.4.1962).
Weitere Verfahren:
USP 3 366679 (Merck & Co.; ert. 30.1.1968; Prior. 11.10.1962, 19.9.1963). DOS 2 302 937 (Tanabe; Anm. 22.1.1973; J-Prior. 22.1.1972).
Neue Synthese fiir Methyl-vanillylketon:
USP4 169 858 (Merck & Co.; ert. 2.10.1979; Prior. 31.12.1976, 6.3.1978).
Aldometil® (Sharp & Dohme)
Caprinol® (Bayer)-Komb.
Methyldopa (Stada Chemie)
Presinol® (Bayer)
Sembrina® (Boehringer Mannh.)
Aldomet® (Merck Sharp & Dohme) Hydromet® (Merck Sharp & Dohme)-Komb.
GB: Aldomet® (Merck Sharp & Dohme) Dopamet® (Berk)
I: Aldomet® (Merck)
Medopren® (Dietopharma) Presinol® (Bayer)
Sembrina® (Boehringer Biochemia)
584 M Methyldopa - Methylergometrin - Methylmethioninsulfonium-chlorid bzw. -bromid
Aldomet® (Merck-Banyu) Becanta® (Kissei)
Dansul® (Nihon Yakko) Destens® (Nissin) Dopamin® (Hokuriku) Hyperten® (Toho) Metholes® L (Taisho)
Methyldopa (Mitsui)
Nichidopa® (Nichiiko)
Polinal® (Boehringer-Yamanouchi) USA: Aldomet® (Merck Sharp & Dohme) Aldoclor® (Merck Sharp & Dohme) Aldoril® (Merck Sharp & Dohme)
Methylergometrin
(Methylergonovin)
113-42-8 7054-07-1 Maleinat 6209-37-6 Tartrat
Uterotoriicum;
Wehenmittel
(+ )-/V-[l-(hydroxymethyl)propyl]lysergamide
H3C
D-Lysergsaure-azid
CH2-0H NH + H5C2-CH-NH2
(+)-2-Amino-
butanol
0
HO--CH2 ll I A H5C2-CH-NH
H3C
Methylergometrin
H3C
d-lsolysergsaure-azid
CH2“0H
H5C2-CH-NH2
(+)_2-Amino-
butanol
d-tsolysergsaure-(-»)-t-hydroxy-2-butylamid
[KOHj /Isomerisierung
Methylergometrin
USP 2 265 207 (Sandoz; ert. 1941; CH-Prior. 1939).
D: Methergin® (Sandoz)
F: Methergin® (Sandoz)
I: Methergin® (Sandoz)
J: Levospan (Isei)
Methergin® (Sandoz-Sankyo)
Metenarin® (Teikoku Zoki) Ryegonovin® (Morishita) USA: Ergotrate® Maieate (Lilly) Methergine® (Sandoz)
Methylmethionin- 1115-84-0 Chlorid Ulcustherapeuticum
sulfonium-chlorid 3493-11-6 Jodid
bzw. -bromid
(Methiosulfonii chloridum; MMS; Vitamin U)
* sulfonium, (3-amino-3-carboxypropy])dimethyK chloride, l- and bromide, respectively
CH3Cl bzw. CH3Br H3C-S-CH2-CH2-CH-COOH *77. „ K
J ‘ ‘ | Methylehlond bzw.
-bromid
^S—CH2—CH2—CH — COOH НзС NH2
Methylmethioninsulfomum-chlorid bzw. -bromid
Methylmethioninsulfonium-chlorid bzw. -bromid - Methyloestrenolon M 585
DBP 1 239 697 (Degussa; Anm. 20.2.1963).
Therapie von Nierenerkrankungen:
USP 4 122 189 (Kaken; eit. 24.10.1978; J-Prior. 31.3.1976). GB-P 1 538 000 (Kaken; Anm. 30.3.1977; J-Prior. 31.3.1976). DOS 2 714 391 (Kaken; Anm. 31.3.1977; J-Prior. 31.3.1976). Hypolipidamische Wirkung:
K. Seri et al., Arzneim.-Forsch. 28, 1711 (1978).
D: Vitamin U (Trommsdorff)
F: Ardesyl®{Beytout)
Lobarthrose® (Opodex)
J: Cabagin® (Kowa)
Gaston U® (Tokyo Hosei) Kizankohl U® (Sanko)
New U-TIV® (Zeria)-Komb.
New Edion-U® (SS Seiyaku) Nichigreen U® (Nichiiko) Showa U (Showa)
U-vit. (Hamari)
Vitas U® (Kaken)
Yucron® (Daigo Eiyo)
Ко mb. - Praparate
Methyloestrenolon
(Methylestrenolone; Normethandrone; Normethandrolone)
514-61-4
Gestagen
! estr-4-en-3-one,17-hydroxy-17-methyl-, (17/3)-
♦ СгОз
Orthoameisensaure-
triethylester
Nortestosteron Chrom(Vl)-
(Nandrolon, s. S. 619) oxid
h5c2o'
t. CH3MgBr 2. [H*]
1. Methyl -magnesium-bromid
Methyloestrenolon
H3C0‘
3- 0,17a- Dimethy I -11(3-oestradiol
Lithium /Ammomak
Methyloestrenolon
H3C0‘
3-0-Methylestron
[Oestron-3-methylether]
1, U/NH3
2. СГО3/СН3СООН
1. Lithium/Ammomak
2. ChromlVD-oxid
Methyloestrenolon
586 M Methyloestrenolon - Methylpentynol - Methylphenidat
a, b C. Djerassi et al., J. Am. Chem. Soc. 76, 4092 (1954). с USP 2744 122 (Syntex; ert. 1956; MEX-Prior. 1951).
USP 2774 777 (Syntex; ert. 1956; Prior. 1952).
C. Djerassi et al., J. Am. Chem. Soc. 76,4092 (1954).
Weiteres Verfahren:
USP 2 849 461 (P. de Ruggieri; ert. 1958; Anm. 1957).
D: Gynakosid® (Boehringer Mannh.)-Komb. USA: Methalutin® (Parke-Davis)
F: Orgasteron® (Organon)
Methylpentynol 77-75-8 Sedativum
(Meparfynoi)
3-methy|-l-pentyn-3-oI
H-C=C-H + Na(oder NaNH^) Acetylen
C=0
CH3 I
H5C2-C-CECH| OH ! Methylpentynol
DRP 285 770 (Bayer; 1913).
DRP 289 800 (Bayer; 1913).
DRP 291 185 (Bayer; 1914).
D: Allotropal® (Heyl)
F: N-Oblivon® (Latema)-Methylpentynolcarbamat GB: Insomnol® (Medo)
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