Атлас заболеваний полости рта - Ланге Р.П.
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Methaqualon 72-44-6 Hypnoticum 340-56-7 Hydrochlorid
2-methyl-3-o-tolyl-4(3//)-quinazolinone
ocNH / + Nn oxychlond CH3
N- Acetyl- o-Tolutdm anthranilsaure (2-Methyl-amtin) Methaqualon
DOT 9,245(1973). GB-P 843 073 (Labs. Toraude; Anm. 22.8.1958; USA-Prior. 9.5.1958). J. Klosa, J. Praia. Chem. [4], 20,283 (1963).
D: Normi-NoxВ® (Herbrand) OptinoxanВ® (Robisch) Pro DormВ® (Schiirhoiz) RevonalВ® (Cascan) F: DivinoctalВ® (I.S.H.)-Komb. IsonoxВ® (Ucepha)-Komb. MandraxВ® (I.S.H.)-Komb, GB: RevonalВ® (Merck) J: HyminalВ® (Eisai) MeroctanВ® (Sanwa) NeneВ®(Sankyo) NormoresfВ® (Doitsu-Aoi) OreolonВ® (Kobayashi) USA: Parestв„ў (Parke-Davis) QuaaludeВ® (Rorer) SomnafacВ® (Cooper) SoporВ® (Amar-Stone)
Methazolamid 554-57-4 Diureticum
(Carboanhydrase-Inhibitor)
/V-(4-methyl-2-sulfamoyl-42-l,3,4-thiadiazolin-5-ylidene)acetamide
Methazolamid - Methdilazin - Methestroldipropionat M 577
N-N _
h3c-co-nh'^s-^~s-ch2h^>
2-Acetamino-5-benzylthio-
1,3,4-lhiadiazol
[CHjONa]
N-N
H3C-CO-N^s-^-S-CH2-<^>
Methyl-
jodid
t. C(2/CH3COOH/H20 2. NHj
H3c
N-N
0-N ^J^so ,-N
jH3C-CO“M' 'S'
; Methazolamid
USP 2 783 241 (American Cyanamid; ert. 1957; Prior. 1955).
F: NeptazaneВ® (Theraplix) USA: NeptazaneВ® (Lederle)
J: NeptazaneВ® (Lederle)
Methdilazin
1982-37-2
1229-35-2
Hydrochlorid
Antiallergicum;
Antihistaminicum
10-[(l-methyl-3-pyrrolidinyl)methyl]phenothiazine
c,_CHl~Cl
o
H
Phenothiazin
NaNH2
Natrium-
amid
1-Methyl-3-chior-
methylpyrrolidin
I
CH-
:_On
ch3
USP 2 945 855 (Mead Johnson; ert. 19.7.1960; Prior. 21.10.1958). DBP 1049 382 (Cilag; Anm. 1956; CH-Prior. 1955).
GB: DilosynВ® (Duncan, Flockhart)
USA: TacarylВ® (Westwood)
Methestroldipropionat
84-13-9
130-73-4 Methestrol
Oestrogen
4,4'-(l,2-diethylethylene)di-o-cresol-dipropionate
H3C
HsC2~C0 — О—4 Al/Hg w C2H5
3-Methyl-i-propiony|oxy- Alunn>rВ»unn-
propiophenon amalgam
v H5C2 C2H5
У~%—с-сЛо-со-с
H5C2-C0-0-^ \)_o-C0-C2Hs
3J4-8В«s-(3-methy'i-i-proprony<oxypheny(]-3J4-hexandiol
578 M Methestroldipropionat - Methocarbamol - Methohexital
РЅ3СЃ CH3
РЎРќСЉРЎРћРЎ1/(РќРіРЎ-РЎРћ}20
Acetyl -chlond
S^-Bis-fS-methyt-i-propionytoxyphenyU-S^-hexadien
H2 /Ra-N* oder Pd
H5C2 —co-c
•0-C0-C2H5
Methestroldipropionat
V. Niederl et al., J. Am. Chem. Soc. 70, 508 (1948). Weitere Verfahren: L. M. Marson, Boll. Chim. Farm. 102, 317 (1963). J. H. Burckhalter, R. J. Seiwald, J. Org. Chem. 24,445 (1959).
USA: MepraneВ® (Reed & Camrick)
Methocarbamol 53203-6 Muskelrelaxans
3-(c?-methoxyphenoxy)-l, 2-propanediol 1-carbamate
1. C0CI2
3-(2Methoxyphenoxy)-propan-
1,2-dioi (Guaiphenesin, s. S. 449)
Methocarbamol
USP 2 770 649 (Robins; ert. 1956; Prior. 1955). H. L. Yale et al., J. Am. Chem. Soc. 72,3710 (1950).
D: RobaxinВ® (Brenner)
RobaxisalВ® (Brenner)
MethocabalВ® (Zeria) MethocalВ® (Daiko)
TraumacutВ® (Brenner)
F: LumirelaxВ® (Sarbach)-Komb. GB: RobaxinВ® (Robins)
NichirakishinВ® S (Nichiiko) OhlaxinВ® (Ohta)
USA: DelaxinВ® (Femdale)
Robaxisal ForteВ® (Robins) I: MiowasВ® (Wassermann)
J: CarbametinВ® (Uji)
MiowasВ® (Wassermann) CarbametinВ® (Uji) CarxinВ® (Kanto)
RobamolВ® (Cenci) RobaxinВ® (Robins) RobaxisalВ® (Robins)
Methohexital
(Methohexitone)
18652-93-2 22151-68-4 Na-Salz
Narkoticum
(В±)-5-allyl-l-methyl-5-(l-methyl-2-pentynyl)barbituricacid (a-form)
Methohexital - Methotrexat M 579
H5C2-C=C-H + 'c-CH3 + HgC2—MgBr -► H5C2-C=C-CH-OH PBr’
0
{! I PhosthorHIl)-
CH3 bromid
Acetal- Ethylmagne- 3-Hexin-2-ol
dehyd siumbromid
H5C2-C=C-CH-Br
CH3
2-Brom-3-hexin
2. HjC4
COOCjH5
2. Ma(onsaure-diethylester
COOC,H I 2 H5C2-C=C-CH-CH
COOC,H,
H3C
2n5
V Na
2. H2C=CH-CH2-
H2C=CH-CH2 COOC2H5
H5C2-C=C-CH 4COOC2H5 CH3
I ch3
I O^N^O
rf2C=CH—CH2-I NH H5C2-C=C-CH g I СНэ
1 Methohexital
USP 2 872448 (Eli Lilly; ert. 3.2.1959; Prior.4.4.1956).
D: BrevimytalВ®-Natrium (Lilly) USA: BrevitalВ® Sodium (Lilly)
GB: BrietalВ® Sodium (Lilly)
Methotrexat 59-05-2 Cytostaticum
(Amethopterin) (Folsaure-Antagonist)
A/-[^-[[(2,4-dia/nino-6-pteridinyl)methyl]methylamino]-benzoylJ-L-(+)-glutamic add
0 COOH COOH
02N-<f y—c' + H2N-CH-CH2-CH2-COOH Na0H » O2N—v y—CO—NH — CH —CH2—CH2 —COOH
\—/ \
Cl
i-Nitrobenzoylchlorid L-Glutaminsaure
COOH
h2n^^co-nh-ch-ch2-ch2-cooh
A/-( l* -Aminobenzoyl ] - L -glutaminsaure
H3C-NH-^^>“CO-NH-CH-CH2-CH2-COOH N-[i* - Met hylaminobenzoyU-L-glutaminsaure
nh2
uTT ' 'c-CH-CHi-BrjpH 3,0-3, s| H2N N N>12 РЅ
2,Рђ,5,Р±-РўРµ?РіР°- 2,3-Oibromproparal aminopyrimidiPi
РјС†, CH3 COOH
? 2 1 1
,CH2 — N 4>-CO-NH-CH-CH2-CH2-COOH
IT T
Methotrexat
580 M Methotrexat - Methoxamin - Methoxsalen
DOT 8,426 (1972).
D. R. Seeger et al., J. Am. Soc. 71,1753 (1949).
Weitere Verfahren:
J. R. Piper u. J. A. Montgomery, J. Heterocycl. Chem. 11,279 (1974).
M. Chaykowsky et al., J. Med. Chem. 17,1212 (1974).
DOS 2 741270 (US-Secr. of Commerce Nat. Techn. Inform. Service; Anm. 14.9.1977; USA-Prior. 17.11.1976).
USP 4 057 548 (J. Wiecko; ert. 8.11.1977; Prior. 11.11.1975,30.3.1976).
