- ..
( ):
Q2N—^>-(;_o-CH2-CHj-NH-CH2-CH-CH3
CH3
О СНз
I нгм—V_Jy-C-0-CH2-CH2-NH-CH2-CH-CH3|
DOT 15,368 (1979).
USP 2 139818 (NovocoJ Chem.; ert. 1938; Prior. 1935).
USA: Dentocaine® (Amer. Chem.) Monocaine® hydrochloride (Philadelphia Labs.)
Monocaine® formate (Novocol)
Blltizid 2043-38-1 Diureticum;
(Buthiazide; Antihypertonlcum
Thiabutazide)
6-chloro-3,4-dihydro-3-isobutyl-2H-l,2,4-benzo-thiadiazine-7-sulfonamide 1,1-dioxide
I H ",
» СНз [ CI^N CH2-CH-CH,
T If + с-сн,-сн-сн, -» I T jr T
H2N-S02'^'4S02-NH2 o7 H2N-SOj'^^'S'
02
5-Ch(or-2,6-d5aminosulfo- Isovaleraldehyd | Butizid
nylanilin (6-Amino-i-chlor- (3-Methytbutanal)
benzobl^-disulfamid)
(vgl. Chlorcthiazi<i-Synthese, S. 794)
GB-P 861 367 (Ciba; Anm. 2.3.2959; USA-Prior. 9.4.1958, 9.6.1958, 29.7.1958, 29.9.
I. H. Werner et al., J. Am. Chem. Soc. 82,1161 (1960).
D: Aldactone® 50-Saltucin®
(Boehringer Mannh.-Searle)-Komb.
Inrensain® 150-Mode noJ®
(Boehringer Mannh.-Cassella)-Komb. F:
Modenol® (Boehringer Mannh.)-Komb.
Butorphanol 42408-82-2 Analgeticum
54244-71-2 Tartrat
Saltucin® (Boehringer Mannh.) Sembrina®-Saitucin® (Boehringer- Mannh. )-Komb. Eunephran® (Servier)
17-(cycJobutylmethyl)morphinan- 3,14-diol
130 В Butorphanol
7-Methoxytetratan
H3CO''
1 NaH I terf - A»myl»lWohol
2 Bf —iCH?k~Br r 2. 1,4-Dibrombutan
CH2
CN
uaih4 /thf
H3CO
7-Methoxy-2,2-tetra-
methylentetralon
o-C,H9Li/CHiCN/THF , -80°C t Butvl- Aceto-lithium nrtril
НзСО''
HO
HCI/IC2H5J20
CH2 CH2-NH2
H3CO
OCQQC3H5 / Pyndin /СНгС!^
Chlorameisen-
saureethylester
NaH / terf-Amylalkohol
H3CO
H3CO
W-Ethoxycarbonyt-U hydroxy- 3-methoxyiso-morphinan
/CHiClz
3-Chlorper-
ben2oesaute
POCb / Pyndin
H3CO
CQOC2HS
H3CO
W-Ethoxycarbony\ -3-methoxy -^в,1й -morphinan
H3CO
3-Methoxy-^8'U-
morphinan
| ( /Pyndin
Cyctobutan*
caroonsaure-
chlorid
H3CO
H3CO
LiAIH4/THF
Cl
b-'
ООН
3-Cfclorper-
benzoesaure
CH2
--o
H3CO
HO
1 Pyridir • HCl Oder ИВг 2. Racematspattung mit (-)-Wemsaure
Butorphanol
Butorphanol - Butriptylin - Butropiumbromid В 131
DOF2,231 (1977); 3,330(1978).
USP 3 775 414 (Bristol-Myers; ert. 27.11.1973; Anm. 10.5.1972).
USP 3 819 635 (Bristol-Myers; ert. 25.6.1974; Prior. 8.9.1971, 13.1.1972).
DOS 2 243 961 (Bristol-Myers; Anm. 7.9.1972; USA-Prior. 8.9.1971,13.1.1972). DOS 2 265 255 (Bristol-Myers; Anm. 7.9.1972; USA-Prior. 8.9.1971, 13.1.1972). DOS 2 265 256 (Bristol-Myers; Anm. 7.9.1972; USA-Prior. 8.9.1971, 13.1.1972). USP 3 980 641 (Bristol-Myers; ert. 14.9.1976; Anm. 31.7.1975).
J. Monkovic et al., J. Am. Chem. Soc. 95, 7910 (1973).
Alternativsynthesen: aus 7-Methoxy-2-tetralon;
USP 4 017 497 (Bristol-Myers; ert. 12.4.1977; Anm. 18.11.1975).
aus ( — )-l-(4-Methoxybenzyl)-2-methyl-l,2,3,4,5,6,7,8-octahydroisochinoIin:
USP 4115 389 (Bristol-Myers; ert. 19.9.1978; Anm. 2.5.1977).
USA: Stadol® (Bristol)
dl-10, 11 -dihydro- N,N,p- trimethyl-5 H-dibenzo[a,rf]cyclo-heptene-5-propylamme
Butriptylin
35941-65-2
5585-73-9 Hydrochlorid
Antidepressivum
0
5-Oxo-10,11-di-hydro- 5 H-dibenzo (a,d]-cyclohepten (Oibenzosuberon)
3-Dimethylamino-2-methyl-pfopylchlorid bzw. - magnesium -chlond
СНз
Butriptylin
Belg-P 613 750 (Ayerst; Anm. 9.2.1962; CDN-Prior. 10.2.1961). USP 3 409640 (Sobering Corp.; ert. 5.11.1968; Anm. 22.7.1959).
GB: Evadyne® (Ayerst)
I: Evadene® (Ayerst)
Butropiumbromid 29025-14-7 Spasmolyticum
8-(P'biitoxybenzyl)-3a-hydroxy-laH,5aH-tropanium bromide (— )-tropate
132 B/C Butropiumbromid - Butylscopolammoniumbromid - Cafedrin
с4н9о-(^^-снгВг + НзС
v о-со-сн-сн2он 6
4-Butoxybenzylbromid Hyoscyamm
DOS 1 950 378 (Eisai Kabushiki Kaisha; Anm. 6.10.1969; J-Prior. 18.2.1969). USP 3 696 110 (Eisai Kabushiki Kaisha; ert. 3.10.1972; J-Prior. 18.2.1969).
J; Coliopan® (Eisai)
H3C"N'
Br- CH2^J>-0CtH9
V 0-C0-CH-CH2QH
6
Butropiumbromid
Butytscopolammonium- 149-64-4 Spasmolyticum
bromid
(Butylscopolaminbromid; Scopolamin-butyl bromid; Hyoscin-butylbromid)
* 1 aH,5aH-tropanium. 8-butyl-6fi,7^-epoxy-3a-hydroxy-, bromide, (-)-tropate
CH3
0-C0-CH-CH2-0H * H9Ct-Br 6
Scopolamin Butytbromid
DBP 856 890 (Boehringer Ing.; Anm. 1950).
D: Buscopan® (Boehringer lng.)
F: Algo-Buscopan (Deiagrange)-Komb.
GB: Buscopan® (Boehringer Ing.)
I: Buscopan® (Boehringer Ing.)
Salfagin® (Saif)
Spasmamma® (Chemil) Tranquo-Buscopan® (Boehringer)-Komb.
J: Antispasmin® (Green Cross)
Bubusco-S® (Sawai)
Buscopan® (Boehringer-Tanabe) Buscoridin® (Kanebo)
Buscote® (Kotani)
Buspon® (ToyoP.)
Butiboi® (Towa)
Butylpan® (Hokuriku)
Cafedrin 58(66-83-'
3039-97-2
Sutylscopolammonium-bromid !
Butymide® (Ohta)
Bulysco® (Kobayashi) Diastc®-M (Fukuchi-Fujizoki) Hyoscomin® (Vitacain) Hyospan® (Toiyo)
Moryspan® (Beppu) Reladan®(Isei)
Scobro® (Ono)
Scobron® (Mohan) Scobutylamin® (Horii) Scordin®-B (Ono)
Scorpan® (Kanto)
Sparicon® (Yamanouchi) Spasmopan® (Nichiiko) Stibron® (Iwaki)
Kreislauf-Analepticum Hydrochlorid
