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( ): pharmazeutischewirkstoffe1982.djvu
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V
I
CH2
CHZ
2-Chior-10-(3-chlor_
propyt)*phenothjazin
/—^
HN N-CH3
1-Methyl-
piperazin
N‘
Cl
CH2
I
CH2
ch2-n n-ch3
Prochlorperazin
2-Chtorphenothiazin
Ct-CH2-CH2'CH2-N^_^N-CH3
1-(3-Chlorpropyl)-4-methylpiperazin
Prochlorperazin
DOT 9,228(1973).
USP 2 902484 (Rhone-Poulenc; ert. 1.9.1959; GB-Prior. 1954). DBP 1 037 461 (Rhone-Poulenc; Anm. 1955; GB-Prior. 1954).
F: Tememil® (Specia)
GB: Stemetil® (May & Baker)
Vertigon® (Smith Kline & French) I: Stemetil® (Farmitalia)
J: Nibromin® A (Maruko)
Novamin® (Shionogi)
Pasotomin® ( Yoshitomi)
USA: Compazine® (Smith Kline & French)
Procyclidin - Profenamin - Progesteron P 765
Procyclidin
77-37-2 1508-76-5 Hydrochlorid
Antiparkinson-Mittel
a-cyclohexyl-a-phenyl-1 -pyrrolidinepropanol
(CH20)„ f С-СН2-СНг-М^]
0
Acetophenon Paraform- Pyrrolidm ш-Pyrrotidinopropiophenon
Paraform-
aldehyd
erombenzot bzw.Phenyl-magneskjfti-bromd
04_CHj-Ch2-,Q
0
H2/P!0
L»n
^>-C-CM2-CH2-nQ
о
Procyclidin
USP 2 682 543 (Burroughs Wellcome; ert. 1954; Prior. 1951). USP 2 891890 (Burroughs Wellcome; ert. 1959; Prior. 1952). Alternate v- Sy nthesen:
USP 2 826 590 (Lilly; ert. 1958; Anm. 1954).
USP 2 842 555 (Burroughs Wellcome; ert. 1958; Anm. 1954).
D: Osnervan® (Wellcome)
F: Kemadrine® (Wellcome)
GB: Kemadrin® (Burroughs Wellcome)
I: Kemadrin® (Wellcome)
J: Kemadrin® (Chugai)
USA: Kemadrin® (Burroughs Wellcome)
Profenamin 522-00-9 Neurolepticum;
(Ethopropazine) 1094-08-2 Hydrochlorid Ant/parkinson-Mittef
10-(2-diethylaminopropyl)phenothiazine
Phenothiazin
1 . NaNHj
/a He 2.CI-CH-CH2-N I \
CH3 C2He
(lsocnef«ntr«nmjng durch Kristallisation)
! Natriumamid 2J-Oiethylamino-2-propylchlorid
N v ^jHs ch2-ch-n 1 V и
СНз C2H5 Profenamin
USP 2526 118 (Rhone-Poulenc; ert. 1950; F-Prior. 1948).
USP 2607 773 (Rhone-Poulenc; ert. 1952; GB-Prior. 1949).
F; Parsidol® (Sevenet) J: Parkin® (Yoshitomi-Takeda)
GB: Lysivane® (May & Baker) USA: Parsidol® (Wamer-Chilcott)
Progesteron 57-83-0
pregn-4-ene-3,20-dione
Gestagen
766 P Progesteron - Proglumid
V»o
<^>=0/А|[0-СН(СНз)г13
Cyclo- / Aluminium-tri-hexanon isoproparolat
USP2379 832 (Schering Corp.; ert. 1945;D-Prior. 1936).
R. Oppenauer, Rec. Trav. Chim. Pays-Bas Belg. 56, 137 (1937). Weitere Verfahren:
USP 2 232438 (Schering Corp.; ert. 1941; D-Prior. 1934).
USP 2 420 489 (Parke-Davis; ert. 1947; Prior. 1941).
F. W. Heyl, U. E. Herr, J. Am. Chem. Soc. 72,2617 (1950).
G. Slomp, J. L. Johnson, J. Am. Chem. Soc. 80,915 (1953). Ullmann, 3. Auflage, Bd. 8,660, und dort zitierte Patente. Ullmann, 4. Auflage, Bd. 13,29.
GB:
Biograviplan® (Griinenthal)
Cumorit® (Schering)-Komb. Duogynon® Amp. (Schering)-Komb. Duogynon® Simplex (Schering)-Komb. Proluton® (Schering)
Sistocyclin® (Ciba)-Komb.
Lutogyl® 25 (Roussel)
Percutacrine® Luteinique (Besins-Iscovesco)-Komb.
Progestillin® fort (Knoll France)-Komb. Progestogel® (Besins-Iscovesco) Progestosol® (Besins-Iscovesco) ProJuton®-Oestradiol (SEPPS)-Komb. Synergon® (L’Hepatrol)-Komb. weitere Komb.-Praparate Cyclogest® (Collins)
Gestone® (Paines & Byrne) Glanducorpin® (Albion)
Progestasert® (May & Baker)
Gestone Pabym® (Samil)
Lutociclina® (Ciba)
Progelun® (Ion)
Progestolo® (Negroni)
Proluton® (Schering)
Duogynon® (Nihon Schering)-Komb. Estormon® (Hokuriku)-Komb.
Lutes® (Mochida)-Komb.
Luteum® Depot (Teikoku Zoki)-Komb. Oophormin Luteum® (Teikoku Zoki) Prodiol®(Santen-Yamanouchi)-Komb. Progehormon® (Mochida)
Progenin® (Santen-Yamanouchi) Proluton® (Nihon Schering)
USA; Gesterol® (Fellows-Testagar)
Lipo Lutin® (Parke-Davis)
Lucortcum® (Merck Sharp & Dohme) Luteroid® (Injectable Res.)
Lutocyclin® (Ciba Geigy)
Lutromon® (Endo)
Membrettes® (Witco)
Nalutron® (Winthrop)
Profac® (Kay)
Progelan® (Lannett)
Progestasert® (Alza)
Progesterol® (Smith, Miller & Patch) Progesteron Lilly (Lilly) Progestro-Med® (Medics)
Proluton® (Schering)
Prorone® (Sig)
Syngesterone® (Pfizer)
Syngestrets® (Pfizer) zahlreiche Komb.-Praparate
Proglumid
6620-60-6
Ulcustherapeuticum
DL-4-benzamido- N, N-dipropylglutaramic add
C-Cl + h2n-ch-cooh -* C-NH-CH-COOH
_ О CH2-CH2-COOH 0 CH2-CH2-COOH
Benzoylchlorid од-Glutaminsaure /V-Benzoyl-o.i-glutaminsaure
Proglumid - Proligeston - Prolintan P 767
Dipropytamm
0
/V-Benzoyl-D^ -glutamm-saureanhydrid
>i
C3H7
•C-NH-CH-C-N
II I II Vu
0 CH2 о C3H7
(
CH2-COOH
Proglumid
SA-P 65/4065 (Rotta Research; Anm. 16.7.1965; I-Prior. 31.7.1964).
DAS 1 518 125 (Rotta Research; Anm. 30.7.1965; I-Prior. 31.7.1964).
D: Milid® (Opfermann) I; Millid® (Rotta)
Promid® (Opfermann) J: Promid® (Kaken)
F: Milide® (Fournier Frferes)
Proligeston 23873-85-0 Gestagen
14,17-dihydroxypregn-4-ene-3,20-dione, cyclic acetal with propionaldehyde
Kcf,17of-Dihydroxy- Propionaldehyd Proligeston
progesteron
(aus Reichstein S)
DOT 15, 241 (1979).
D. van der Sijde et al., J. Med. Chem. 15, 909 (1972).
SA-P 681 592 (Koninkl. Nederl. Gist & Spiritusfabriek; Anm. 22.2.1968; NL-Prior. 13.3.1967). Ausgangsverbindung:
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