Атлас лекарственных расний СССР - Цицин Н.В.
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1. H2/Pd-C
2. CH20
OH 0 HO H 0 Minocyclin
DOT 5, 73 (1969); 7,188 (1971); 8,93 (1972).
USP 3 148 212 (American Cyanamid; ert. 8.9.1964; Anm. 22.12.1961).
USP 3 226 436 (American Cyanamid; ert. 28.12.1965; Prior. 24.10.1961, 22.12.1961,17.5.1963).
USP 3 345 410 (American Cyanamid; ert. 3.10.1967; Prior. 14.3.1966,1.12.1966).
R.F.R. Chuich et al., J. Org. Chem. 36,723 (1971).
DBP 1245 942 (American Cyanamid; Anm. 15.5.1962; USA-Prior. 21.10.1961,22.12.1961, 7.2.1962). Reinigung:
DOS 2 309 582 (American Cyanamid; Anm. 26.2.1973; USA-Prior. 11.5.1972).
D: KlinomycinВ® (Lederle) MinocinВ® Vena (Cyanamid)
F: MynocineВ® (Lederie-Novalis) J: MinomycinВ® (Lederle-Takeda)
GB: MinocinВ®(Lederle) USA: MinocinВ®(Lederle)
I: MinocinВ® (Cyanamid) VectrinВ® (Parke-Davis)
604 M- Minoxidil - Mitobronitol - Mitomycin-C
MinOXidil 38304-91-5 Antihypertonicum
16317-69-4
6-amino-l,2~dihydro-l-hydroxy-2-imino-4-piperidinopyrimidine
РЅ
OYnYВ°
„NH
РЈ
Barbitursaure
VV
Yn
Cl
2,^6-Trichlor-
pyrimidin
CI^N^NHz
nh2
B-Chlor-2.4-
diammopyrimidin
CIW4)H
/Рљ0Рќ 2,4-Oichior phenol
'XX
РЁРі
YY
nh2
2J4-Oiamino-6-(2/-dichlorphenoxy) -pynmidin
3-Chlorperoxy-
benzMsaure
В°^N_Nh2
Р“ T nper Рў%
NH3
2/-Diamino-6-(2,4-
dichlorphenoxy)-pynmidin-3-oxid
' 0_N^NH2
j YNj
; NH2
I Minoxidil
DOF 2, 383 (1977); 3,493 (1978).
USP 3 382 247 (Upjohn; ert. 7.5.1968; Anm. 1.11.1965).
USP 3461 461 (Upjohn; ert. 12.8.1969; Anm. 1.1.1965).
USP 3 644 364 (Upjohn; ert. 22.2.1972; Anm. 31.3.1970).
DAS 2114 887 (Upjohn; Anm. 27.3.1971; USA-Prior. 31.3.1970). DOS 2 114887 (Upjohn; Anm. 27.3.1971; US A-Prior. 31.3.1970).
USA: LonitenВ® (Upjohn)
Mitobronitol
488 41 -5
Cytostaticum
1,6-dibromo-1,6-dideoxy-D-mannitol
OH OH H H
lilt ug.
HO-CHz*-C—С—C-C-CH2-OH -^2L-
I I I I H H OH OH
0-Manmt
OH OH H H I
lilt I
-РЎРќ2-РЎ-РЎ-РЎ-РЎ-РЎРќ2-Р’Р“
I I I 1
H H OH OH I
Mitobronitol ,
GB-P 959407 (Chinoin; Anm. 15.9.1961, Рќ-Prior. 15.9.1960, 6.9.1961).
D: MyeJobromolВ® (Hormonchemie) J: MyebrolВ® (Kyorin)
GB: MyelobromolВ® (Berk)
Mitomycin-C
50-07-7
Cytostatlsch wirksames Antibioticum
6-ammo-l,la,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-5-methyIazirino[2',3':3,4]pyrrolo [1.2-a]indole-4,7-dione carbamate (ester)
Mitomycin-C - Mitopodozid - Mitotan M 605
Рѕ
Mitomycin-C
Aus Kulturfiltraten von Streptomyces caespitosus; saulenchromatographische Reinigung
GB-P 830 874 (KyowaHakko; Anm. 8.4.1958; J-Prior. 6.4.1957).
USP 3 042582 (Bristol-Myers; ert. 3.7.1962; Prior. 11.12.1958).
F: AmetyrineВ® (Choay) USA: Mutamycinв„ў (Bristol)
I: Mitomycin-C (Kyowa)
Mitopodozid 1508-45-8 Cytostaticum
podophyllic acid 2-ethylhydrazide
<
H3C0
JpL
OCH3
OCH3
Podophytlotoxin
h2n-nh2
Hydrazin
СЂРЅ
<XCrCHj
CH2-0H
co-nh~nh2
H3C0 0CH3
РѕСЃРё.
1. H3C-CH0
2. H2/Ran*y-Ni
2“ OH
H3CO ^ '0CH3 OCH3
Mitopodozid
USP 3 054802 (Sandoz; ert. 18.9.1962; CH-Prior. 7.10.1960). Hydrazinolyse von PodophyUotoxin:
J. Rutschmann, J. Renz, Helv. Chim. Acta 42, 890 (1959).
ProresidВ® (Sandoz)
Mitotan 53 19-0
l,l-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)-ethane
Cytostaticum
606 M Mitotan - Mofebutazon - Molindon
ci
Cl2CH-CHO + Br —Mg—^ ^'
Dichloracetaldehyd 2-Chlorphenyl-
magnesiumbromid
1-\ f3-CWH,S0(
<v- CH - CHCI2 -5;^^—► h *
1 -{2-Chlorphenyl) -2,2-dichlorethanol
CH-CHCI2
6ra
B. L. Haller et al., J. Am. Chem. Soc. 67,1591 (1945). USA: LysodrenВ® (Calbiochem)
Mofebutazon
2210-63-1
Antirheumaticum;
Antiphlogisticum;
Analgeticum
4-butyl-l-phenyl-3,5-pyrazolidinedione
H9C4-CH-COOC2H5
COOC2H5
Butylmatonsauredi-
ethytester
NH2
Phenyl-hydrazin
? j HgCi Рћ j i I
I Mofebutazon I
GB-P 839057 (Comm. Farmaceutica Milanese; Anm. 27.11.1957; I-Prior. 28.11.1956). J. Biichi et al., Helv. Chim. Acta 36, 75 (1953).
D: MonozolidinumВ® (Hormosan)
F: ArcobutinaВ® (Silbert & Ripert)-Komb.
I: ChemiartrolВ® (Gazzini) MonbutinaВ® (Lafare) ReumatoxВ® (Medosan)
Molindon
7416-34-4
15 622-65-8 Hydrochlorid
Tranquilizer;
Sedativum
3-ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)-indol-4(5W)-one
H3C-CH24 C =
H=C 2 Diethylketan
CH3
HNO; bzw H3c-0NQ2 Methylnrtrit
H0N = C4
c=o
H5C2
Cyclohexan-
1,3-dion
H N
^СЃРЅР· C2H5
3-Ethyl-2-methyl-
A-oxo-i.S^-tetra-
hydroindol
0^_^NH / (РЎРќРі0)Рї
Morpholm / Parafor m-aldehyq
Molindon - Molsidomin - Moperon M 607
DOT 5, 34 (1969); 9,233 (1973); 11,60, 62,69 (1975).
DAS 1 545 774 (Endo Labs.; Anm. 16.10.1965).
USP 3 491093 (Endo Labs.; ert. 20.1.1970; Prior. 2.3.1964,3.4.1964,11.5.1966,29.11.1967). Kombination mit Amantadin (Antidepressivum):
USP 4 148 896 (du Pont; ert. 10.4.1979; Anm. 22.2.1978).
USA: Lidoneв„ў (Abbott) MobanВ® (Endo)
Molsidomin 25717-80-0 Coronardilatator
,Y-carboxy-3-morpholinosydnone imine ethyl ester
NO
> NC —CH2 —NH-N^O Ж-М2-Н
\_/ Formaldehyd/ \_/ \
Cyanwasserstoff N—
4-Ammomor-
pholm
ГЧ—\
Рѕ
//
Cl—С / Pyridin
чосгн5_
Chlorameisen-
saureethyiester
/- NTT
\=m+
H5C2O '=N+
\
