- .
ISBN 5-98657-009-
( ):
Stilboestrol (Richard Daniel)
Stilboestrol and Lactid Acid (Crookes)-Komb.
USA: Acnestrol® (Dermik)
Des PIex®(Arnfre-Gran<)-Komb. Dicorvin® (Amfre-Grant)-Komb. Estrosyn® (Cooper)
Furacin-E® (Eaton)-Komb. Gerex® (Consul. Midland)-Komb. Makarol® (Mallinckrodt) Mase-Bestrol® (Mason)
Micrest® (Beecham)
Stilbelin® (Squibb)
TyJosterone® (Lilly)-Komb. Vagestrol® (Eaton)
Diethylstilboestrol- 130-80-3 Oestrogen
dipropionat
(Diethylstilbestrol-dipropionat; Diathylstilboestrol-dipropionat)
trans-a,a-diethyl-4,4'-stilbenediol dipropionate
/=\ I /=\ [Pyndin]
H°4 ^-C=C-<4 jbOH + |H5C2-C0)20 -
C2Hg
Diethylstilboestrol [ 3,4-Bis- Propionsaure-
14-hydroxyphenyl) - 3-hexen ] anhydrid
E. C. Dodds et al., Proc. R. Soc. London Ser. B. 127,140 (1939).
D: Klimax ,,Taeschner“® (Taeschner)-Komb. I: Komb.-Prap.
Oestro Gynaedron® (Artesan)-Komb. USA: Dibestil® (Breon)
H5c2-co-o^>i=c^>o-co-c2H5
C2H5
Diethylstllboestrol-dipropionat_
Diethylstilboestrol- 316-23-4 Oestrogen
disulfat
(Diethylstilbestroldisulfat; Diathylstilboestroldisulfat)
traits- a,a-diethyl-4,4-stilbendiol disulfate
300 D Diethylstilboestroldisulfat - Difenidol - Difenoxin
C2H5
H°-<Q-C=C-^-0H + CI-SO3H
Diethylstilboestrol [ 3,4-Bis-(4-hydroxyphenyl)-3-hexenj saure
CHorsulfon-
C2Hi
H03S-0-l^-C=C-(Ql-0-S03H I
C,H5
Diethylstilboestrol-disulfat
Di-Katiumsalz
USP 2 234311 (Ciba; ert. 1941; CH-Prior. 1938).
I: Idroeslril® (Maggioni) J: Estiol® (Hokuriku)
Pappy® (Kanto)
Stilbestohormon® (Tokyo Hosei)
Difenidol
(Diphenidol)
972-02-1
3254-89-5 Hydrochlorid 26363-46-2 Pamoat
Antiemeticum;
Antihistaminicum
a,a-diphenyl-l-piperidine butanol
Mg
С1-СНг-СН2-СН2'
■О
Л/-{3-Chlorpropyl)-piperidm (3-Pipendinopropylchlorid)
Cl-Mg-“CH2“CH2-CHz-
Я
6
-о
Сь»
CH2-CH2~CH2-N
о
DOT 3,32(1967).
USP 2 411 664 (Ciba; ert. 1946; CH-Prior. 1941).
J: Ansumin® (SS Seiyaku)
Antiul® (Tokyo Hosei) Cephadoi® (Nippon S.) Cerachidol® (Ono)
Cerrosa® (Toyo Pharmar) Degidole® (Nihon Yakubin) Gipsydol® (Nihon Yakuhin) Maniol® (Morishita)
Meeaimin® (Yoshitomi/Takeda) Meniedolin® (Toyo Shinyaku) Meranom® (Hokuriku)
Midnighton® (Takata)
Pineroro® (Maruko)
Promodor® (Torii)
Satanolon® (Tatsumi)
Sofalead® (Nikken)
Solnomin® (Zensei)
Tatimil® (Mohan)
Verterge® (Nippon Chemiphar) Wansar® (Hoei)
Yophadol® (Yoshindo/Horita) USA: Vontrol® (SmithKline + French)
Difenoxin 28782-42-5 Antidiarrhoicum
35807-36-4 Hydrochlorid
l-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotic acid
Difenoxin - Diflorasondiacetat D 301
CN
— _ru _i/ \/COOC2H5 K0C1CH3);/DMS0/H;0
М-сн2-снг-м^Х
6 О
Diphenoxylat (s. S. 328)
DOT 12, 347(1976).
DAS 1 953 342 (Janssen; Anm. 23.10.1969; USA-Prior. 4.11.1968). USP 3 646 207 (Janssen; ert. 29.2.1972; Anm. 4,11.1968).
D: Lyspafen® (Cilag-Chemie)
Diflorasondiacetat
33564-31-7
2557-49-5 Diflorason
Glucocorticoid
6a,9-difluoro-ll/3,17,21-trihydroxy-16/3-methylpregna-l,4-diene-3,20-dione-17,21-diacetate
H3C-CO-O-CH2.
V^o
'C'=S‘J 1 (F3C-CO)20/CH3COOH/[H3C-<f3—SO3H ]
-OH w
|l н [ Vch3
H3C-C0-0-CH2,
2 HjC-CO-NH-Br
3 КОСОСНз /Aceton
2)-Acetoxy-3,20-dioxo-6er-f luor-17-hydroxy-16/3-methyl-4,9 (11)-pregnadien
1. Trifluoressigsaureanhydrid /Essigsajre/ p-Toluolsulfonsaure
2 N-Bromacetamid
3 Kaliumacetal
1. H2F2/THF NC CN
2o=tb 0 / Dioxar Cl Cl 1. Fluorwasserstoff 2 2,3-0|с1ог-5,6-й1-cyano-l,&-t>enzo-efttnon 1DDQ)
■-О —СО—CH3
0 i V CH3
H3C-C0-0-CH2s
HO^ ^1/.0-CO-CH3
H T V-CH3
Diflorasondiacetat
HO-CH2.
НзС'
ОСНз
I
-C-OCH3
I
ОСНз
K-Q-
SOjH]
p-Toluolsulfonsaur*
6a,9a- Difluor-3,2Q-dioxo-16/9-methyl-11/Э, 17,21-tri-hydToxy-1,£-pregnadien [Diflorason]
Orthoessigsaure-
tnmethylester
I СНэОН/рНЗ 2. [Н3С-СО)гО/Руп<}|п
Diflorasondiacetat
302 D Diflorasondiacetat - Diflucortolonvalerianat
DOF 2,238 (1977); 3, 331, 906 (1978).
DOT 15,445(1979).
USP 3 980778 (Upjohn; ert. 14.9.1976; Anm. 20.5.1975; Prior. 25.10.1973, 20.12.1972,9.3.1972). NL-P 7 303 262 (Upjohn; Anm. 8.3.1973; USA-Prior. 9.3.1972, 20.12.1972).
^usgangsverbindung:
USP 3 557 158 (Upjohn; ert. 19.1.1971; Prior. 22.1.1962,18.3.1959, 4.8.1958).
D; Florone® (Upjohn) USA: Florone® (Upjohn)
Diflucortolonvalerianat
(Dillucortolonvalerat)
59198-70-8
2607-06-9 Diflucortolon
Glucocorticoid
6a,9-difluorO'll/3 ,21-dihydroxy-16a-methylpregna-l,4-diene-3,20-dione-21-pentanoate
H3C-C0-0“CH24
+ H3C-S02C]
H3C” CO—0—CH2
(Pyndin 1 /QMF '
21-Acetoxy-3,20-dioxo-Sa- Methansul-fluor-11/3-hydroxy-16a-methyl- fonylchlorid
4-pregnen
(s. Ruocortolon-Syntbese, S. 417)
Sf
\ j /Dioxar/HClOt
N, A/'rOibfom-B.S-dimethyt-hydantcin
H3C-CO-O-CH2
mikrobiotogische Dehydnerung \ВаЫ1и$ Lent us MB 284 ]
-CH3
HO-CH2
-снз
1 снэсоок/с2н5он 2. H2F:/CHCh
HgCt — C0C1 / Pyridin
Valeriansaure-
chtorid
H3C-CO-O-CH2,
DOT 12,259(1976).
DBP 1 211 194 (Schering; Anm. 27.7.1963) Zusatzzu DBP 1 169444. DBP 1 169 444 (Schering; Anm. 22.2.1961).
