- .
ISBN 5-98657-009-
( ):
DOT 9, 185(1973). USP 3 562258 (Nordmark; ert. 9.2.1971; Prior. 10.2.1969). GB-P 1185 139 (Nordmark; Anm. 13.2.1969).
D: Enterocura® (Nordmark)
502 - NH-С - NH - С = N
H2N
N] -U-Aminobenzolsulfonyl) -N3-cyan-guanidin
Sulfalen 152-47-6 Chemotherapeuticum
(Sulfametopyrazin) (Depotsulfonamid)
/Y‘-(3-methoxy-2-pyrazmyl)sulfanilamide
H2N..NL
H3C-CO-NH
i-AcetamjdobenzDlsulfonylchlorid
Г
H3C0"'Sr
3-Amino-2-
methoxypyrazin
НзС-СО-NH-^ 7-S°2_NH\/n\
Xi)
H3CO N
IН2Ы—y-SOz-ЫН
mco"4r Sulfalen
Vorprodukt:
.N-^NH2
CT
^ M
Br; /СН3СООН
N'
2-Aminopyraztn
H;/Pd-C) f^VNH2
Вг'Ч^ОСНз N^0CH3
Sulfalen-Sulfamerazin-Sulfamethizol S 839
^Nv^-C0-NH2
3-Hydroxypyrazin-
2-carboxamid
Cl'"
4N^S;t
3-Chlor-2-
cyanopyrazin
NaOCH3
flCN
^N^OCHs
2-Cyana-3-
methoxypyrazin
H^Oj / NaOH
Ю—NHz
^N^OCH3
3-Methoxypyrazin-
2-carboxamid
.N^NH2
С iC
XN^OCH3
USP 3 098 069 (Farmitalia; ert. 16.7.1963; GB-Prior. 14.7.1959).
D: Longum® (Montedison Pharma) I: Kelfizina® (Farmitalia)
GB: Keifizine-W® (Montedison)
Sulfamerazin
(Methylsulfadiazin)
127-79-7
Chemotherapeuticum
/V1-(4-methyl-2-pyrimidinyl)sulfanilamide
NHj
H2n4
NH
Guantdm
CH3
o=c.
CH2
I
Acetessigsaure-
ethylester
СНЗ
II
H2N N О H
CH3
М'Ц
Л J<
H2^ N Cl
CH3
SO2—Cl f Pyridin
й-AcetamidoCenzolsulfonylcMorid
2 Amino 4-methylpyrimidin
CH3
N
H3C - CO - NH—S02 -
CH31
S02-NH^N
USP 2 407 966 (Sharp & Dohme; ert. 1946; Anm. 1940).
D: Dosulfin® (Geigy)-Komb. I: Polagin® (de Angeli)-Komb.
F: Solumedine® (Specia) J: Romezin® (Tanabe)
Sulfamethizol 144-82-1
N1 -(5-methyl-1,3.4-thiadiazol-2-yl)sulfanilamide
Chemotherapeuticum
840 S Sulfamethizol - Sulfamethoxazol und Cotrimoxazol
OzN-SO2 —Cl + o2N-f^)-SOj-NHvSvCH!
W N-H W M-N
4-Nitrobenzolsulfonyl- 5-Ammo-2-methyl~ chlond 1,3,4-thiadiazol
b
SH
НзС-CO-NH—V у— SO2 — Cl + H2N-C
4N-N = CH-CH3
Д-Acetamidobenzoisulfonylchlorid Acetaldehyd-lhiosemi-carbazon
I H2N-<Q>“S02-NH^.S^cH3
N-N
Sulfamethizol
SH
/ Кз| FclCNlg
C-CO - S02-N
N — N = CH CH3 cyanoferrat(UI)
JJ \\ ' л» г*1Ы1ц ...
НзС—CO —N>—SO2-NH-C —-- — > Sulfamethizol
4 ' ^ Kalium-hexa-
a USP 2 358 031 (American Cyanamid; ert. 1944; Prior. 1940). b USP 2 447 702 (Lundbeck & Co.; ert. 1948; DK-Prior. 1942).
D: Spasmo Urosulf® (TAD)-Komb. J: Hamway® (Nichiiko)
Urosulf® (TAD)-Komb. Salimol® (Maruishi-Kanebo)
F: Rufol® (Debat) Urokinon® (Chugai)
GB: Urolucosil® (Warner) Urokizol® (Chugai)
Г: Rufol® (Roussel Maestretti) Urosol® (Kanto)
Thiosulfil® (Ayerst) Urosul® (Mohan)
USA: Thiosulfil® (Ayerst)
Sulfamethoxazol 723-46-6 Chemotherapeuticum und Cotrimoxazol (Urogenitaltrakt)
JV'-(5-methyl-3-isoxazolyl)sulfanilamide
h2n.
НзС-СО-NH—SO2-CI + Y\ -*■ НгС-С0-ЫН-^~\-50г-ЫН
W N'O^CHs W )r\
N v,KCH,
Л-Acetamidobenzolsulfonylchlorjd 3-Amino-5-
methylisoxazol
NaOH
Sulfamethoxazol
DOT7,189(1971).
USP 2 888 455 (Shionogi; ert. 26.5.1959; J-Prior. 4.9.1956).
Sulfamethoxazol und Cotrimoxazol - Sulfamethoxydiazin S 841
D: Bactrim® (Roche)-Komb.*
Drylin® (MerckJe)-Komb.*
Eusaprim® OWel]come)-Komb. * Osmat® (Boehringer Mannh.)-Komb.* Supristol® (Minden)-Komb.*
F: Bactrim® (Roche)-Komb.*
Eusaprim® (Wellcome)-Komb.*
* Komb. mit Trimethoprim = Cotrimoxazol; vgl.
Gantanol® (Roche)
GB: GanlanoJ® (Roche)
J: Bacta® (Nippon Roche)-Komb. * Seprim® (Shionogi)-Komb.* Sinomin® (Shionogi)
USA: Azo Gantanol® (Roche) Gantanol® (Roche)
Sulfamethoxydiazin
(Sulfameter)
651-06-9
Chemotherapeuticum
(Depotsulfonamid)
' sulfanilamide, N'-(5-methoxy-2-pyrimidinyl)-
NH HcCoO-C // \
H3N-C4 + CH-OCH3
NH2 h5c2o-c^
0
Methoxymalonsaure-diethylester
[ NaOC;Hs |
Guamdin
(-carbonat)
,0
H2N—^ V-OCH3 H 0
Phospfior-
oxychiorid
Cl
N_(
H2N-<f \)— ОСНз N=<
Cl
2-Ammo-4,6-<itch(or 5-methoxypyrimidin
HzN—(y у—ОСНз
HjC-CO-NH-^J-SOz-CI
4-Acetamidobenzolsiilfonyichiorid
2-Ammo-5-methcxy-pynmidin
H3C—CO —NH—^—SO2—NH—^ J^-0CH3
H2N—S0Z-NH—f _J>-0CH3 Sulfamethoxydiazin
H3C
N
- CO - NH SO 2 ~ NH -
NH2
HsC20-C,
H5C20-C'
рН-ОСНз
(4-Acetamidobenzo(su[fonyl)-guanidjn
Methoxymalonsaure-
diethylester
OH
N
H3C—CO —NH—S02—NH-^ —OCH3 OH
1 POCh
2. Zn/NaOH
3. NaOH
Sulfamethoxydiazin
DBP 1 101 428 (Schering AG; Anm. 8.7.1959).
D: Durenat® (Bayer/Schering) F: Bayrena (Bayer Pharma)
GB: Durenate® (Bayer) USA: Sulla® (Robins)
842 S Sulfamethoxypyridazin - Sulfametrol
Sulfamethoxypyridazin 8O-35-3 Chemotherapeuticum
(Sulphamethoxypyridazin)
A,1-(6-inethoxy-3-pyridazinyl)sulfamlamide
HjN-lf-^>-S02-NH-<f^V'Cl + NaOCH3 \=/ n=N
6-Chlor-3-(4-aminobenzolsulfonyl- Natrium-
amido)-pyridazin methylat
(Sulfachlorpyndazin. s. S. 633)
USP 2 712012 (American Cyanamid; ert. 1955; Prior. 1954). A^-Acetyl-Derivat: USP 2 833 761 (American Cyanamid; ert. 1958; Anm. 1957).
D: Davosin® (Parke-Davis)
Lederkyn® (Novaiis Arzn.)
F: Sulmidal® (Roger Bellon)-Komb.
