Атлас Гематология - Андерсон Ш.
ISBN 5-98657-009-Х
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l,2,3,4,10,14b-hexahydro-2-methyldibenzo[c, /]-pyrazino[l,2-a]azepine
Ttiymolepticum
600 Рњ Mianserin - Mibolerone
Р°.
РЎРќР· I
HN-CH2-CH2-OH
^СЃРЅ-РѕРЅ
I
СЃРЅР·
N
Styroloxid 2-Methylaminoethanol нзС^ ^СНг—CH?-
Р°
CH-Cl
I
СЃРЅРі
i
H3C CH2-CH2-CI
Z^Aminofterizyt-
alkohol
Polyphosphor-
saure
DOT 12, 31(1976).
DOS 2 505 239 (Akzo; Anm. 7.2.1975; NL-Prior. 9.2.1974).
Medizin. Anwendung:
USP 4128 641 (HZJ Research Center; ert. 5.12.1978; Prior. 31.7.1975, 28.2.1977). Altere Verfahren:
DOS 1 695 556 (Organon; Anm. 9.3.1967; NL-Prior. 12.3.1966).
USP 3 534 041 (Organon; ert. 13.10.1970; NL-Prior. 12.3.1966).
W. J. Van der Burg et al., J. Med. Chem. 13, 35 (1970).
D: TolvinВ® (Organon) GB: NorvalВ® (Bencard)
F: AthmylВ® (Organon) BolvidonВ® (Organon)
I: LantanonВ® (Ravasini)
Mibolerone 3704-09-4 Orales Kontraceptivum;
Anabolicum
17/3-hydroxy-7a,17-dimethylestr-4-en-3-one
1. РЎРќСЌРњРґР’Рі
2. NaOH
1. Methyl- * magnesium-bromid
3,17 - Dioxo -7a -methyl -19 -
nor-4-androsten-3-pyrroli-
dylenamin
(aus 3,17-0io*o-7В«-methyl-l?-nor-i-androsten)
DOF 1,247(1976).
DOT 15, 34(1979).
USP 3 341 557 (Upjohn; ert. 12.9.1967; Prior. 5.6.1961, 6.11.1960, 6.6.1958). FP-M 4521 (Upjohn; Anm. 4.6.1962; USA-Prior. 5.6.1961).
Weiteres Verfahren:
J. A. Campbell, J. C. Babcock, J. Am. Chem. Soc. 81,4069 (1959).
Trenniing der 7a, 7/S-Isomeren:
NL-P6601 855 (Ciba; Anm. 14.2.1966; CH-Prior. 15.2.1965).
GB: MatenonВ® (Upjohn)
USA: ChequeВ® (Upjohn)
Miconazol - Midecamycin M 601
Miconazol 22916-47-8 Fungicid
22832-87-7 Nitrat
l-[2,4-dichloro-jf?-[(2,4-dichlorobenzyl)oxy]phenethyl]-imidazole
r nh
N=s/
Br-CH2. ^0 O'"
w-Brom- 2,4-dichlor-acetophenon
Ыъ/" CH2^C^°
Cl
1-(2(4-DichlorbenzoyU methyU-imidazol (2,4-Dichlor-w-{1 -imidazolyt) -acetophenon]
^N-CH2—CH—OH N^/ 1 •
1-12,4-Dichlorphenyt)-
2-{1-imidazolyl)-ethanol
2. Br-CHj-^-CI
1. Natnumftydnd
2. 2,4-Oichlorbenzylbromid
DOT7,192 (1971); 8, 229 (1972).
DAS 1 940388 (Janssen; Anm. 8.8.1969; USA-Prior. 19.8.1968, 23.7.1969). USP 3 717 655 (Janssen; ert. 20.2.1973; Anm. 19.8.1968).
D:
F:
GB:
DaktarВ® (Janssen) Epi-MonistatВ® (Cilag-Chemie) Gyno-DaktarВ® (Janssen) Gyno-MonistatВ® (Cilag-Chemie) DaktarinВ® (LeBrun) Gyno-DaktarinВ® (LeBrun) DaktacortВ® (Janssen)
DaktarinВ® (Janssen)
DermonistatВ® (Ortho) Gyno-DaktarinВ® (Janssen) MonistatВ® (Ortho)
I: DektarinВ® (Janssen)
MicotefВ® (Italfarmaco)
USA: MicatinВ® (Johnson & Johnson) MonistatВ® (Ortho)
Midecamycin
(Espinomycin, Mydecamycin)
35457-80-8
Antibioticum
7-(formylmethyl)-4,10-dihydroxy-5-methoxy-9>16-dimethyl-2-oxooxacyclohexadeca-ll,13-dien-6-yl 3,6-dideoxy-4-0-(2,6-dideoxy-3-C-methyi-a-L-rffco-hexopyranosyl)-3-(dimethyIamino)jS -D-glucopy-ranoside 4',4"-dipropionate (ester)
OH
oc*
fCH3
-0-C0-CH2 u-rA-0-СЃРѕ-СЃРќРі-СЃРЅСЌ > I CH3
-Os/ CH3
Midecamycin
602 M Midecamycin - Midodrin - Minaprin
Aus Fermentationslosungen von
a Streptomyces mycarofaciens Shomura und Niida nov. sp. oder b Streptomycesplatensis Subsp. rnaivin'as MCR1.0388
DOT 10,62(1974).
a T. Niida et al., J. Antibiot. 24,321,452 (1971).
A. Kinumaki et al., J. Antibiot. 27,102,107 (1974).
Struktur:
S. Inouye et al., J. Antibiot. 24,461 (1971).
F: MidecacineВ® (Clin Midy) J: MedemycinВ® (Meiji)
Midodrin 42794-76-3 Antihypotonicum 3092-17-9 Hydrochlorid
2-amino-N-(2,5-dimethoxy-/3-hydroxyphenethyl)acetamide
РћРЎРќР· РѕСЃРЅСЌ 0
^ " <ri_c ...... "
<^J>-c-ch2-nh2 * ci-c-chj-ci -в–є ^J>-C-CH2-NH-C-CH2-CI NalrJm_
H3C0 0 H3CO 0
С€-Рђ mino- 2,5 - Dimet hoxy - Chloracetylchlorid acetophenon
РЇРЅ> Рѕ ! /0РЎРќР· Рѕ
^>-c-ch2-nh-c-ch2-n3 •^,^/.Pd C|> <^JHch-ch2-nh-c-ch2-nh2
borhydrid / r\u
II
H3C0 , H3C0
I
I Midodrin
DAS 2 523 735 (Lentia; Anm. 28.5.1975; A-Prior. 24.7.1974).
Weitere Verfahren:
Oe-P 241435 (Oesterr. Stickstoffwerke Linz; Anm. 11.6.1963; Laufzeit ab 15.12.1964). DOS 2 506 110 (Lentia; Anm. 13.2.1975).
Belg-P 838 512 (Chemie Linz AG; Anm. 12.8.1976; D-Prior. 13.2.1975).
D: GutronВ® (Hormon-Chemie)
Minaprin 25905-77-5 Antidepressivum 25953-17-7 Dihydrochlorid
4-[2-[(4-methyl-6-phenyl-3-pyridazinyl)amino]ethyl]morpholine
З-СЫог-k -methyl- W-(2-Aminoethyl)-morphoiin
6-phenyipyridazin
Minaprin - Minocyclin M 603
DOF2, 811(1977).
DOS 2229 215 (СЕРВЕРЕ; Anm. 15.6.1972; GB-Prior. 18.6.1971). GB-P 1 345 880 (СЕРВЕРЕ; Laufzeit ab 16.6.1972; Prior. 18.6.1971). SA-P 730671 (СЕРВЕРЕ; Anm. 3.1.1973).
F: CantorВ® (Clin-Comar-Byla)
Minocyclin 10118-90-8 Antfbioticum
13614-98-7 Hydrochlorid
4,7-bis(dimethylamino)-l,4>4a,5,5a,6,ll,12a-octahydro-3,lG,12,12a-tetrahydroxy-l,ll-dioxo-2-naph-
thacenecarboxamide
HO H N(CH3)Z ' в–
'co-nh2
OH 0 HO fj 6-Demethyl tetracyclin
•OH
co-nh2
KNOj/
HFIfllssjg)
РћРќ Рћ РќРћ С† 0
H РЅ ^,РЎРќР·)2 OH
o2n-
OH 0 H0 H о •
РЅ РЅВҐ(РЎРќ*
co-nh2
CO-NH,
OH 0 Hojjo
N02 N(CH3)2
: ,.0H
co-nh2
OH 0 HO H 0
H3Ct-0NO/HzS0t
Sutylnjtnt
N02 h h NICHalj в– ! ^OH
^РЈРўРіРў'РЎ0'РЅРЅ*
OH 0 HO В° 0
